共 75 条
Testosterone and Cardiovascular Health
被引:84
作者:

Elagizi, Andrew
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机构:
Leonard J Chabert Med Ctr, Dept Internal Med, Houma, LA USA Leonard J Chabert Med Ctr, Dept Internal Med, Houma, LA USA

Kohler, Tobias S.
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机构:
Mayo Clin, Dept Urol, Rochester, MN USA
Mayo Clin, Coll Med, Rochester, MN USA Leonard J Chabert Med Ctr, Dept Internal Med, Houma, LA USA

Lavie, Carl J.
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h-index: 0
机构:
Univ Queensland, Sch Med, Dept Cardiovasc Dis, John Ochsner Heart & Vasc Inst,Ochsner Clin Sch, New Orleans, LA USA Leonard J Chabert Med Ctr, Dept Internal Med, Houma, LA USA
机构:
[1] Leonard J Chabert Med Ctr, Dept Internal Med, Houma, LA USA
[2] Mayo Clin, Dept Urol, Rochester, MN USA
[3] Mayo Clin, Coll Med, Rochester, MN USA
[4] Univ Queensland, Sch Med, Dept Cardiovasc Dis, John Ochsner Heart & Vasc Inst,Ochsner Clin Sch, New Orleans, LA USA
关键词:
ANDROGEN DEPRIVATION THERAPY;
CHRONIC HEART-FAILURE;
CORONARY-ARTERY-DISEASE;
INTIMA-MEDIA THICKNESS;
LOW SERUM TESTOSTERONE;
LOW PLASMA TESTOSTERONE;
PROSTATE-CANCER;
DOUBLE-BLIND;
ELDERLY-MEN;
METABOLIC SYNDROME;
D O I:
10.1016/j.mayocp.2017.11.006
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
There is an ongoing debate in the medical community regarding the effects of testosterone on cardiovascular (CV) health. For decades, there has been conflicting evidence regarding the association of endogenous testosterone levels and CV disease (CVD) events that has resulted in much debate and confusion among health care providers and patients alike. Testosterone therapy has become increasingly widespread, and after the emergence of studies that reported increased CVD events in patients receiving testosterone therapy, the US Food and Drug Administration (FDA) released a warning statement about testosterone and its potential risk regarding CV health. Some of these studies were later found to be critically flawed, and some experts, including the American Association of Clinical Endocrinologists and an expert panel regarding testosterone deficiency and its treatment, reported that some of the FDA statements regarding testosterone therapy were lacking scientific evidence. This article summarizes the current evidence regarding the relationship between testosterone (endogenous and supplemental) and CV health. A literature review was conducted via search using PubMed and specific journal databases, including the New England Journal of Medicine and the Journal of the American College of Cardiology. Key search terms included testosterone and cardiovascular health, coronary artery disease, heart failure, androgen deprivation therapy, intima-media thickness, and adrenal androgens. Initial study selection was limited to publications within the past 10 years (January 1, 2007, through December 31, 2016); however, key publications outside of this time frame were selected if they provided important quantitative data or historical perspectives for the review of this topic. The search was further supplemented by reviewing references in selected articles. (C) 2017 Mayo Foundation for Medical Education and Research
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页码:83 / 100
页数:18
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Zhang, Anqi
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Choong, Karen
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Lakshman, Kishore M.
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h-index: 0
机构:
Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Mazer, Norman A.
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Miciek, Renee
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h-index: 0
机构:
Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Krasnoff, Joanne
论文数: 0 引用数: 0
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机构:
Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Elmi, Ayan
论文数: 0 引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Knapp, Philip E.
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Brooks, Brad
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

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Aggarwal, Sheetal
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Bhasin, Geeta
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h-index: 0
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Hede-Brierley, Leif
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Bhatia, Ashmeet
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h-index: 0
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

论文数: 引用数:
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LeBrasseur, Nathan
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Fiore, Louis D.
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h-index: 0
机构:
VA Boston Healthcare Syst, Jamaica Plain, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

Bhasin, Shalender
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Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
Boston Med Ctr, Boston, MA USA Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
[10]
Quantifying Observational Evidence for Risk of Fatal and Nonfatal Cardiovascular Disease Following Androgen Deprivation Therapy for Prostate Cancer: A Meta-analysis
[J].
Bosco, Cecilia
;
Bosnyak, Zsolt
;
Malmberg, Anders
;
Adolfsson, Jan
;
Keating, Nancy L.
;
Van Hemelrijck, Mieke
.
EUROPEAN UROLOGY,
2015, 68 (03)
:386-396

Bosco, Cecilia
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Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England

Bosnyak, Zsolt
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Ferring Pharmaceut, Clin R&D, Copenhagen, Denmark Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England

Malmberg, Anders
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Ferring Pharmaceut, Clin R&D, Copenhagen, Denmark Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England

Adolfsson, Jan
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Karolinska Inst, Stockholm, Sweden Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England

Keating, Nancy L.
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机构:
Harvard Univ, Sch Med, Boston, MA USA
Brigham & Womens Hosp, Boston, MA 02115 USA Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England

Van Hemelrijck, Mieke
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Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London WC2R 2LS, England