Testosterone and Cardiovascular Health

被引:84
作者
Elagizi, Andrew [1 ]
Kohler, Tobias S. [2 ,3 ]
Lavie, Carl J. [4 ]
机构
[1] Leonard J Chabert Med Ctr, Dept Internal Med, Houma, LA USA
[2] Mayo Clin, Dept Urol, Rochester, MN USA
[3] Mayo Clin, Coll Med, Rochester, MN USA
[4] Univ Queensland, Sch Med, Dept Cardiovasc Dis, John Ochsner Heart & Vasc Inst,Ochsner Clin Sch, New Orleans, LA USA
关键词
ANDROGEN DEPRIVATION THERAPY; CHRONIC HEART-FAILURE; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA THICKNESS; LOW SERUM TESTOSTERONE; LOW PLASMA TESTOSTERONE; PROSTATE-CANCER; DOUBLE-BLIND; ELDERLY-MEN; METABOLIC SYNDROME;
D O I
10.1016/j.mayocp.2017.11.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is an ongoing debate in the medical community regarding the effects of testosterone on cardiovascular (CV) health. For decades, there has been conflicting evidence regarding the association of endogenous testosterone levels and CV disease (CVD) events that has resulted in much debate and confusion among health care providers and patients alike. Testosterone therapy has become increasingly widespread, and after the emergence of studies that reported increased CVD events in patients receiving testosterone therapy, the US Food and Drug Administration (FDA) released a warning statement about testosterone and its potential risk regarding CV health. Some of these studies were later found to be critically flawed, and some experts, including the American Association of Clinical Endocrinologists and an expert panel regarding testosterone deficiency and its treatment, reported that some of the FDA statements regarding testosterone therapy were lacking scientific evidence. This article summarizes the current evidence regarding the relationship between testosterone (endogenous and supplemental) and CV health. A literature review was conducted via search using PubMed and specific journal databases, including the New England Journal of Medicine and the Journal of the American College of Cardiology. Key search terms included testosterone and cardiovascular health, coronary artery disease, heart failure, androgen deprivation therapy, intima-media thickness, and adrenal androgens. Initial study selection was limited to publications within the past 10 years (January 1, 2007, through December 31, 2016); however, key publications outside of this time frame were selected if they provided important quantitative data or historical perspectives for the review of this topic. The search was further supplemented by reviewing references in selected articles. (C) 2017 Mayo Foundation for Medical Education and Research
引用
收藏
页码:83 / 100
页数:18
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