FBI-1 functions as a novel AR co-repressor in prostate cancer cells

被引：53

作者：

Cui, Jiajun ^{[1
,2
]}

Yang, Yutao ^{[3
]}

Zhang, Chuanfu ^{[1
]}

Hu, Pinliang ^{[2
]}

Kan, Wei ^{[2
]}

Bai, Xianhong ^{[2
]}

Liu, Xuelin ^{[1
]}

Song, Hongbin ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Dis Control & Prevent, Beijing 100071, Peoples R China

[2] Biotech Pharmaceut Co Ltd, Beijing 100176, Peoples R China

[3] Capital Med Univ, Beijing Inst Neurosci, Beijing 100069, Peoples R China

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Androgen receptor; FBI-1; Gene expression; POZ domain; Co-repressor; ANDROGEN RECEPTOR TRANSACTIVATION; TRANSCRIPTION FACTOR; NUCLEAR RECEPTOR; MOLECULAR-MECHANISMS; POZ DOMAIN; CYCLIN D1; N-COR; COREPRESSORS; POKEMON; GENE;

D O I：

10.1007/s00018-010-0511-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pro-oncogene FBI-1, encoded by Zbtb7a, is a transcriptional repressor that belongs to the POK (POZ/BTB and Kruppel) protein family. In this study, we investigated a potential interaction between androgen receptor (AR) signaling and FBI-1 and demonstrated that overexpression of FBI-1 inhibited ligand-dependent AR activation. A protein-protein interaction was identified between FBI-1 and AR in a ligand-dependent manner. Furthermore, FBI-1, AR and SMRT formed a ternary complex and FBI-1 enhanced the recruitment of NCoR and SMRT to endogenous PSA upstream sequences. Our data also indicated that the FBI-1-mediated inhibition of AR transcriptional activity is partially dependent on HDAC. Interestingly, FBI-1 plays distinct roles in regulating LNCaP (androgen-dependent) and PC-3 cell (androgen-independent) proliferation.

引用

页码：1091 / 1103

页数：13

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