Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

被引：130

作者：

Rinaldi, Andrea ^{[1
,2
]}

Mian, Michael ^{[1
,2
,3
]}

Chigrinova, Ekaterina ^{[1
,2
]}

Arcaini, Luca ^{[4
]}

Bhagat, Govind ^{[5
,6
,7
]}

Novak, Urban ^{[5
,6
,7
]}

Rancoita, Paola M. V. ^{[1
,2
,9
]}

De Campos, Cassio P. ^{[1
,2
,9
]}

Forconi, Francesco ^{[8
]}

Gascoyne, Randy D. ^{[10
]}

Facchetti, Fabio ^{[11
,12
]}

Ponzoni, Maurilio ^{[13
,14
]}

Govi, Silvia ^{[13
,14
]}

Ferreri, Andres J. M. ^{[13
,14
]}

Mollejo, Manuela ^{[15
]}

Piris, Miguel A. ^{[15
]}

Baldini, Luca ^{[16
]}

Soulier, Jean ^{[17
,18
]}

Thieblemont, Catherine ^{[17
,18
]}

Canzonieri, Vincenzo ^{[19
,20
]}

Gattei, Valter ^{[19
,20
]}

Marasca, Roberto ^{[21
]}

Franceschetti, Silvia ^{[22
,23
]}

Gaidano, Gianluca ^{[22
,23
]}

Tucci, Alessandra ^{[11
,12
]}

Uccella, Silvia ^{[24
]}

Tibiletti, Maria Grazia ^{[24
]}

Dirnhofer, Stephan ^{[25
]}

Tripodo, Claudio ^{[26
]}

Doglioni, Claudio ^{[10
]}

Dalla Favera, Riccardo ^{[5
,6
,7
]}

Cavalli, Franco ^{[1
,2
]}

Zucca, Emanuele ^{[1
,2
]}

Kwee, Ivo ^{[1
,2
,9
]}

Bertoni, Francesco ^{[1
,2
]}

机构：

[1] Oncol Inst So Switzerland, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland

[2] Oncol Inst So Switzerland, Lymphoma Unit, CH-6500 Bellinzona, Switzerland

[3] Azienda Osped S Maurizio, Div Hematol, Bolzano, Italy

[4] Univ Pavia, Policlin San Matteo, Fdn Ist Ricovero & Cura Carattere Sci IRCCS, Div Hematol, I-27100 Pavia, Italy

[5] Columbia Univ, Inst Canc Genet, Dept Pathol, New York, NY USA

[6] Columbia Univ, Inst Canc Genet, Dept Genet & Dev, New York, NY USA

[7] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA

[8] Univ Siena, Dept Clin Med & Immunol Sci, Div Hematol & Transplant, I-53100 Siena, Italy

[9] Ist Dalle Molle Studi SullIntelligenza Artificia, Manno, Switzerland

[10] British Columbia Canc Agcy, Dept Pathol, Vancouver, BC V5Z 4E6, Canada

[11] Spedali Civili Brescia, Div Hematol, Brescia, Italy

[12] Univ Brescia, Dept Pathol, Serv Anat Patol 1, Brescia, Italy

[13] Ist Sci San Raffaele, Pathol Unit, Milan, Italy

[14] Ist Sci San Raffaele, Unit Lymphoid Malignancies, Milan, Italy

[15] Ctr Nacl Invest Oncol, Programa Patol Mol, Madrid, Spain

[16] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Hematol Bone Marrow Transplantat Unit, Milan, Italy

[17] Univ Paris Diderot, Hop St Louis, Hematol Lab, Paris, France

[18] Univ Paris Diderot, Hop St Louis, Serv Hematooncol, Paris, France

[19] IRCCS, Ctr Riferimento Oncol, Div Pathol, Aviano, PN, Italy

[20] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, Aviano, PN, Italy

[21] Univ Modena & Reggio Emilia, Dept Hematol & Oncol, Div Hematol, Modena, Italy

[22] Amedeo Avogadro Univ Eastern Piedmont, Div Hematol, Dept Clin & Expt Med, Novara, Italy

[23] Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy

[24] Univ Insubria, Osped Circolo, Anat Pathol Unit, Varese, Italy

[25] Univ Basel, Inst Pathol, Basel, Switzerland

[26] Univ Palermo, Dept Human Pathol, Palermo, Italy

来源：

BLOOD | 2011年 / 117卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

B-CELL LYMPHOMA; NF-KAPPA-B; GENE-EXPRESSION; SOMATIC MUTATIONS; SPLENIC LYMPHOMA; INSIGHTS; DELETION; SURVIVAL; FREQUENT; GAIN;

D O I：

10.1182/blood-2010-01-264275

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients 25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs. (Blood. 2011; 117(5): 1595-1604)

引用

页码：1595 / 1604

页数：10

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