Synthesis and characterization of polymeric soybean oil-g-methyl methacrylate (and n-butyl methacrylate) graft copolymers:: Biocompatibility and bacterial adhesion

被引:64
作者
Çakmakli, B
Hazer, B [1 ]
Tekin, IÖ
Cömert, FB
机构
[1] Zonguldak Karaelmas Univ, Fac Arts & Sci, Dept Chem, TR-67100 Zonguldak, Turkey
[2] Zonguldak Karaelmas Univ, Fac Med, Dept Immunol, TR-67100 Zonguldak, Turkey
[3] Zonguldak Karaelmas Univ, Fac Med, Dept Med Microbiol, TR-67100 Zonguldak, Turkey
关键词
D O I
10.1021/bm050063f
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Peroxidation, epoxidation, and/or perepoxidation reactions of soybean oil under air at room temperature resulted in cross-linked polymeric soybean oil peroxides on the surface along with the waxy soluble part, sPSB, with a molecular weight of 4690, containing up to 2.3 wt % peroxide. This soluble polymeric oil peroxide, sPSB, initiated the free radical polymerization of either methyl methacrylate (MMA) or n-butyl methacrylate (nBMA) to give PSB-g-PMMA and PSB-g-PnBMA graft copolymers. The polymers obtained were characterized by H-1 NMR, thermogravimetric analysis, differential scanning calorimetry, and gel permeation chromatography techniques. Polymeric oil as a plasticizer lowered the glass transition of the PSB-g-PMMA graft copolymers. PSB-g-PMMA and PSB-g-PnBMA graft copolymer film samples were also used in cell culture studies. Fibroblast and macrophage cells were strongly adhered and spread on the copolymer film surfaces, which is important in tissue engineering. Bacterial adhesion on PSB-g-PMMA graft copolymer was also studied. Both Staphylococcus epidermidis and Escherichia coli adhered on the graft copolymer better than on homo-PMMA. Furthermore, the latter adhered much better than the former.
引用
收藏
页码:1750 / 1758
页数:9
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