Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

被引：194

作者：

Nasery, Mahshid Moballegh ^{[1
,2
,3
]}

Abadi, Banafshe ^{[1
]}

Poormoghadam, Delaram ^{[4
]}

Zarrabi, Ali ^{[5
]}

Keyhanvar, Peyman ^{[6
,7
]}

Khanbabaei, Hashem ^{[8
]}

Ashrafizadeh, Milad ^{[9
]}

Mohammadinejad, Reza ^{[10
]}

Tavakol, Shima ^{[11
]}

Sethi, Gautam ^{[12
]}

机构：

[1] Kerman Univ Med Sci, Student Res Comm, Kerman 7619813159, Iran

[2] Kerman Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Kerman 7616911319, Iran

[3] USERN, Nanomed Res Assoc, Tehran 7616911319, Iran

[4] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Med Nanotechnol, Pharmaceut Sci Branch,IAUPS, Tehran 1916893813, Iran

[5] Sabanci Univ Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[6] Tabriz Univ Med Sci, Fac Pharm, Res Ctr Pharmaceut Nanotechnol, Tabriz 5165665811, Iran

[7] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Med Nanotechnol, Tabriz 5165665811, Iran

[8] Ahvaz Jundishapur Univ Med Sci, Sch Med, Med Phys Dept, Ahvaz 6135715794, Iran

[9] Univ Tabriz, Fac Vet Med, Dept Basic Sci, Tabriz 5166616471, Iran

[10] Kerman Univ Med Sci, Neurosci Res Ctr, Inst Neuropharmacol, Kerman 7616911319, Iran

[11] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran 1449614525, Iran

[12] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

来源：

MOLECULES | 2020年 / 25卷 / 03期

关键词：

curcumin; cancer; nanocarriers; biopolymer; exosomes; ASSEMBLING PEPTIDE NANOFIBER; PLGA-PEG NANOPARTICLES; TARGETED DRUG-DELIVERY; BOVINE SERUM-ALBUMIN; CANCER PREVENTION; IN-VITRO; ANTIOXIDANT ACTIVITY; PHYSICOCHEMICAL PROPERTIES; EXTRACELLULAR VESICLES; PROTEIN NANOPARTICLES;

D O I：

10.3390/molecules25030689

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such as cancers, a number of them have displayed issues associated with their solubility, bioavailability, and bio-degradability. In the present review, we focus on curcumin, an important and widely used polyphenol, with diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic, anti-viral, etc. Notwithstanding, it also exhibits poor solubility and bioavailability that may compromise its clinical application to a great extent. Therefore, the manipulation and encapsulation of curcumin into a nanocarrier formulation can overcome these major drawbacks and potentially may lead to a far superior therapeutic efficacy. Among different types of nanocarriers, biological and biopolymer carriers have attracted a significant attention due to their pleiotropic features. Thus, in the present review, the potential protective and therapeutic applications of curcumin, as well as different types of bio-nanocarriers, which can be used to deliver curcumin effectively to the different target sites will be discussed.

引用

页数：28

共 200 条

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