IKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker?

被引：99

作者：

Stanulla, Martin ^{[1
]}

Cave, Helene ^{[2
,3
]}

Moorman, Anthony, V ^{[4
]}

机构：

[1] Hannover Med Sch, Pediat Hematol & Oncol, Hannover, Germany

[2] Robert Debre Hosp, AP HP, Dept Genet, Paris, France

[3] Paris Diderot Univ, St Louis Res Inst, INSERM U1131, Paris, France

[4] Newcastle Univ, Wolfson Childhood Canc Ctr, Leukaemia Res Cytogenet Grp, Newcastle Upon Tyne, Tyne & Wear, England

来源：

BLOOD | 2020年 / 135卷 / 04期

基金：

欧盟第七框架计划;

关键词：

MINIMAL RESIDUAL DISEASE; HIGH-RISK; IKAROS GENE; ERG DELETION; IMPACT; CLASSIFICATION; CHILDREN; RELAPSE; STRATIFICATION; IDENTIFICATION;

D O I：

10.1182/blood.2019000813

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Improved personalized adjustment of primary therapy to the perceived risk of relapse by using new prognostic markers for treatment stratification may be beneficial to patients with acute lymphoblastic leukemia (ALL). Here, we review the advances that have shed light on the role of IKZF1 aberration as prognostic factor in pediatric ALL and summarize emerging concepts in this field. Continued research on the interplay of disease biology with exposure and response to treatment will be key to further improve treatment strategies.

引用

页码：252 / 260

页数：9

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