Flavonoids from Salvia chloroleuca with α-Amylsae and α-Glucosidase Inhibitory Effect

被引：2

作者：

Asghari, Behvar ^{[1
,2
]}

Salehi, Peyman ^{[2
]}

Sonboli, Ali ^{[3
]}

Ebrahimi, Samad Nejad ^{[2
,4
]}

机构：

[1] Imam Khomeini Int Univ, Fac Engn & Technol, Dept Plant Prod & Breeding, Qazvin, Iran

[2] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, GC, Tehran, Iran

[3] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Biol, GC, Tehran, Iran

[4] Univ Basel, Div Pharmaceut Biol, CH-4056 Basel, Switzerland

来源：

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2015年 / 14卷 / 02期

关键词：

Salvia chloroleuca; alpha-amylase; alpha-glucosidase; Enzyme inhibition; Flavonoids; AMYLASE; GLYCOSIDES; CONSTITUENTS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It is believed that the inhibition of carbohydrate hydrolyzing enzymes including alpha-amylase and alpha-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. Medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. In our study four flavonoids, namely luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide(2), diosmetin 7-O-glucuronide (3) and salvigenin (4) were isolated from aerial parts of Salvia chloroleuca. The inhibitory activity of these compounds against alpha-amylase and alpha-glucosidase were evaluated. Compounds 1, 2 and 3 showed potent alpha-glucosidase inhibitory effect with IC50 values of 18.3, 14.7, and 17.1 mu M, respectively. Also these compounds exhibited moderate alpha-amylase activity with IC50 values 81.7, 61.5, and 76.3 mu M, respectively.

引用

页码：609 / 615

页数：7

共 25 条

[21] Inhibition of α-glucosidase and α-amylase by flavonoids [J].