An updated review of mesoporous carbon as a novel drug delivery system

被引：20
作者：
Attia, Mohamed S. [1 ]
Hassaballah, Mohamed Y. [2 ]
Abdelqawy, Mohab A. [2 ]
Emad-Eldin, Mahmoud [3 ]
Farag, Aya K. [2 ]
Negida, Ahmed [4 ,5 ]
Ghaith, Hazem [6 ]
Emam, Sherif E. [1 ]
机构：
[1] Zagazig Univ, Dept Pharmaceut, Fac Pharm, Zagazig 44519, Egypt
[2] Zagazig Univ, Fac Pharm, Zagazig, Egypt
[3] Zagazig Univ, Dept Pharm Practice, Fac Pharm, Zagazig, Egypt
[4] Zagazig Univ, Zagazig Univ Hosp, Zagazig, Egypt
[5] Zagazig Univ, Fac Med, Zagazig, Egypt
[6] Al Azhar Univ, Fac Med, Cairo, Egypt
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2021年 / 47卷 / 07期
关键词：
Mesoporous carbon; biocompatibility; drug delivery; stimuli-responsive; controlled release; nanoparticles; ORAL BIOAVAILABILITY; CONTROLLED-RELEASE; SILICA; CARRIER; NANOPARTICLES; DISSOLUTION; IMPROVE; NANOCAPSULES; NANOSPHERES; DOXORUBICIN;
D O I：
10.1080/03639045.2021.1988097
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The nanotechnology approach has been recently adopted to provide more reliable, effective, controlled, and safe drug delivery systems. Nanostructured materials have gained great interest, including siliceous and carbonaceous nanoparticles. The effectiveness of mesoporous carbon nanoparticles (MCNs) in tumor imaging, targeting, and treatment is urging for more future studies. MCNs possess superior properties such as their biocompatibility, large surface area, large pore volume, tunability, and more responsive behavior to internal and external release triggers. These outstanding features make MCNs more applicable for stimuli-responsive drug delivery than the conventional forms of mesoporous silica nanoparticles (MSNs) and other carbon nanoparticles. In this review, we outlined the latest updates regarding the safety, benefits, and potential applications of MCNs.
引用
收藏
页码：1029 / 1037
页数：9
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