Autophagy in cellular metabolism and cancer

被引：200

作者：

Jiang, Xuejun ^{[1
]}

Overholtzer, Michael ^{[1
]}

Thompson, Craig B. ^{[2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2015年 / 125卷 / 01期

关键词：

NONCANONICAL AUTOPHAGY; ATG12-ATG5; CONJUGATE; SELECTIVE AUTOPHAGY; PROTEIN; DEATH; P62; PHOSPHORYLATION; COMPLEX; PROMOTES; GROWTH;

D O I：

10.1172/JCI73942

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Autophagy is a catabolic process mediated by incorporation of cellular material into cytosolic membrane vesicles for lysosomal degradation. It is crucial for maintaining cell viability and homeostasis in response to numerous stressful conditions. In this Review, the role of autophagy in both normal biology and disease is discussed. Emphasis is given to the interplay of autophagy with nutrient signaling through the ULK1 autophagy pre-initiation complex. Furthermore, related cellular processes utilizing components of the canonical autophagy pathway are discussed due to their potential roles in nutrient scavenging. Finally, the role of autophagy in cancer and its potential as a cancer therapeutic target are considered.

引用

页码：47 / 54

页数：8

共 120 条

[81] Parkin-induced mitophagy in the pathogenesis of Parkinson disease [J].

Narendra, Derek ;

Tanaka, Atsushi ;

Suen, Der-Fen ;

Youle, Richard J. .

AUTOPHAGY, 2009, 5 (05) :706-708

[82] Tumor dormancy due to failure of angiogenesis: role of the microenvironment [J].

Naumov, George N. ;

Folkman, Judah ;

Straume, Oddbjorn .

CLINICAL & EXPERIMENTAL METASTASIS, 2009, 26 (01) :51-60

[83] FIP200 regulates targeting of Atg16L1 to the isolation membrane [J].

Nishimura, Taki ;

Kaizuka, Takeshi ;

Cadwell, Ken ;

Sahani, Mayurbhai H. ;

Saitoh, Tatsuya ;

Akira, Shizuo ;

Virgin, Herbert W. ;

Mizushima, Noboru .

EMBO REPORTS, 2013, 14 (03) :284-291

[84] Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation [J].

Noda, Nobuo N. ;

Fujioka, Yuko ;

Hanada, Takao ;

Ohsumi, Yoshinori ;

Inagaki, Fuyuhiko .

EMBO REPORTS, 2013, 14 (02) :206-211

[85] Nix is a selective autophagy receptor for mitochondrial clearance [J].

Novak, Ivana ;

Kirkin, Vladimir ;

McEwan, David G. ;

Zhang, Ji ;

Wild, Philipp ;

Rozenknop, Alexis ;

Rogov, Vladimir ;

Loehr, Frank ;

Popovic, Doris ;

Occhipinti, Angelo ;

Reichert, Andreas S. ;

Terzic, Janos ;

Doetsch, Volker ;

Ney, Paul A. ;

Dikic, Ivan .

EMBO REPORTS, 2010, 11 (01) :45-51

[86] Two ubiquitin-like conjugation systems essential for autophagy [J].

Ohsumi, Y ;

Mizushima, N .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (02) :231-236

[87] p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy [J].

Pankiv, Serhiy ;

Clausen, Terje Hoyvarde ;

Lamark, Trond ;

Brech, Andreas ;

Bruun, Jack-Ansgar ;

Outzen, Heidi ;

Overvatn, Aud ;

Bjorkoy, Geir ;

Johansen, Terje .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (33) :24131-24145

[88] Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation [J].

Polson, Hannah E. J. ;

de lartigue, Jane ;

Rigden, Daniel J. ;

Reedijk, Marco ;

Urbe, Sylvie ;

Clague, Michael J. ;

Tooze, Sharon A. .

AUTOPHAGY, 2010, 6 (04) :506-522

[89] Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene [J].

Qu, XP ;

Yu, J ;

Bhagat, G ;

Furuya, N ;

Hibshoosh, H ;

Troxel, A ;

Rosen, J ;

Eskelinen, EL ;

Mizushima, N ;

Ohsumi, Y ;

Cattoretti, G ;

Levine, B .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (12) :1809-1820

[90] Autophagy and Metabolism [J].

Rabinowitz, Joshua D. ;

White, Eileen .

SCIENCE, 2010, 330 (6009) :1344-1348

← 3 4 5 6 7 8 9 10 11 12 →