Microbial insight into dietary protein source affects intestinal function of pigs with intrauterine growth retardation

被引：38

作者：

Che, Lianqiang ^{[1
,2
]}

Hu, Liang ^{[1
,2
]}

Zhou, Qiang ^{[1
,2
]}

Peng, Xie ^{[1
,2
]}

Liu, Yang ^{[1
,2
]}

Luo, Yuheng ^{[1
,2
]}

Fang, Zhengfeng ^{[1
,2
]}

Lin, Yan ^{[1
,2
]}

Xu, Shengyu ^{[1
,2
]}

Feng, Bin ^{[1
,2
]}

Li, Jian ^{[1
,2
]}

Tang, Jiayong ^{[1
,2
]}

Wu, De ^{[1
,2
]}

机构：

[1] Sichuan Agr Univ, Inst Anim Nutr, Yaan, Sichuan, Peoples R China

[2] Minist Educ, Key Lab Anim Dis Resistance Nutr, Yaan, Sichuan, Peoples R China

来源：

EUROPEAN JOURNAL OF NUTRITION | 2020年 / 59卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Protein source; Pig; Oxidative stress; Low birth weight; Bacteria; SPRAY-DRIED PORCINE; BIRTH-WEIGHT; ANTIOXIDANT CAPACITY; POSTNATAL NUTRITION; COLONIC MICROBIOTA; OXIDATIVE STRESS; BARRIER FUNCTION; IMMUNE FUNCTION; GUT MICROBIOTA; PLANT-PROTEINS;

D O I：

10.1007/s00394-019-01910-z

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Purpose Dietary protein, as important macronutrient, is vital for intestinal function and health status. We aimed to determine the effects of dietary protein source on growth performance and intestinal function of neonates with intrauterine growth retardation (IUGR) in a pig model. Methods Eighteen pairs of IUGR and normal birth weight (NBW) weaned pigs were allotted to be fed starter diet containing soybean protein concentrate (SPC) or spray-dried porcine plasma (SDPP) for 2 weeks. Growth performance, antioxidant variables, intestinal morphology and absorption capability, microbiota composition and short-chain fatty acids (SCFA) were assessed. Results IUGR led to poor growth performance, absorption capability and changes on antioxidant variables, while SDPP diet improved the growth performance, diarrhea index, intestinal morphology and antioxidant variables of IUGR or NBW pigs relative to that fed SPC diet. Importantly, SDPP diet improved bacterial diversity and increased the abundance of phylum Firmicutes, but decreased the phylum Proteobacteria in colonic digesta, associating with higher genera Lactobacillus and lower genera Escherichia-Shigella, linking to the increased concentration of SCFA. Conclusions Our findings indicate that IUGR impairs the growth rate, intestinal function and oxidative status of weaned pigs, which could be partly improved by SDPP diet either for IUGR or NBW pigs, associating with the better antioxidant capability, composition of microbiotas and their metabolites.

引用

页码：327 / 344

页数：18

共 73 条

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