Transition-metal-mediated reactions in combinatorial synthesis

被引：19

作者：

Andres, CJ ^{[1
]}

Whitehouse, DL ^{[1
]}

Deshpande, MS ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Wallingford, CT 06443 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(98)80009-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transition-metal-mediated reactions have played an important role in expanding the scope of combinatorial chemistry from synthesis of peptidic libraries to synthesis of nonoligomeric, small-molecule libraries. Versatile reactions such as heteroannulations, olefin metathesis and dipolar cycloadditions are used for preparation of libraries of historical, as well as novel, pharmacophores. Transition-metal-mediated reactions have also been used strategically to provide 'traceless linkers' in solid-phase synthesis.

引用

页码：353 / 362

页数：10

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