Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones

被引：12

作者：

Nozawa-Kumada, Kanako ^{[1
]}

Matsuzawa, Yuta ^{[1
]}

Ono, Kanako ^{[1
]}

Shigeno, Masanori ^{[1
]}

Kondo, Yoshinori ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, 6-3 Aoba, Sendai, Miyagi 9808578, Japan

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 69期

基金：

日本学术振兴会;

关键词：

C-H ACTIVATION; 3+2 ANNULATION; OXIDATION; AMINATION; DERIVATIVES; MOLECULES; KETIMINES; ALKYNES;

D O I：

10.1039/d1cc02870g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp(3))-H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp(3))-H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp(3))-H bonds and shows excellent functional group tolerance.

引用

页码：8604 / 8607

页数：4

共 46 条

[41] Different Behaviors of a Cu Catalyst in Amine Solvents: Controlling N and O Reactivities of Amide [J].