Self-assembly of penta-selenopeptides into amyloid fibrils

被引：7

作者：

Gokula, Ram P. ^{[1
]}

Mahato, Jaladhar ^{[1
]}

Singh, Harkesh B. ^{[1
]}

Chowdhury, Arindam ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 83期

关键词：

RECEPTOR ANTAGONISTS; AMINO-ACIDS; CONGO RED; BETA; SELENOCYSTEINE; HYDROGELS; PEPTIDES; PROTEIN; PEROXIDASE; OLIGOMERS;

D O I：

10.1039/c8cc06528d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we report the synthesis of a penta-selenopeptide consisting of five benzyl protected selenocysteine residues. This selenopeptide was well characterized by both one- and two-dimensional (D) NMR spectroscopies. We find that the solution conformation is enriched with -sheet structures, which have a propensity to self-assemble and form amyloid fibrils.

引用

页码：11697 / 11700

页数：4

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