Metal-Free Synthesis 6-Benzylphenanthridines via Radical Addition/Cyclization of 2-Isocyanobiphenyls

被引：7

作者：

Lu, Yuling ^{[1
]}

Chen, Li ^{[1
]}

Chen, Xia ^{[1
]}

Yao, Meng ^{[1
]}

Luo, Zengwei ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 02期

基金：

中国国家自然科学基金;

关键词：

phenanthridine; metal-free; radical; isocyanobiphenyl; toluene; ONE-POT SYNTHESIS; OXIDATIVE CYCLIZATION; TOLUENE DERIVATIVES; PHENANTHRIDINES; INSERTION/CYCLIZATION; FUNCTIONALIZATION; DECARBOXYLATION; ISOQUINOLINES; ISOCYANIDES; ISONITRILES;

D O I：

10.1055/s-0039-1690218

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and practical approach has been established for the synthesis of 6-benzylphenanthridines from benzylic hydrocarbons and 2-isocyanobiphenyls via C(sp(3))-H/C(sp(2))-H bond functionalization under metal-free condition. The reaction exhibits good functional group tolerance and delivers the target products in moderate to excellent yields. The preliminary mechanistic investigation revealed that a radical intermediate might be involved in this reaction.

引用

页码：290 / 296

页数：7

共 63 条

[1] New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense [J].