Hedgehog signaling in mammary gland development and breast cancer

被引：55
作者：
Hatsell, Sarah
Frost, Andra R.
机构：
[1] Univ Alabama, Wallace Tumor Inst, Birmingham, AL 35294 USA
[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
[3] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
来源：
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2007年 / 12卷 / 2-3期
关键词：
breast; cancer; mammary gland development; hedgehog; patched; Gli1; Gli2; Gli3;
D O I：
10.1007/s10911-007-9048-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Hedgehog pathway is critical for many developmental processes, including the formation of several epidermal appendages. In the mammary gland strict regulation of the Hedgehog pathway is required for, normal development. Alterations in Hedgehog signaling result in defects in both the embryonic and postnatal mammary gland. Activation of Hedgehog signaling either by mutation or misexpression of pathway members can lead to the development and/or progression of cancers in multiple organs. This review addresses the current understanding and controversies of Hedgehog signaling in mammary gland development and its potential role in promoting breast carcinogenesis and cancer progression.
引用
收藏
页码：163 / 173
页数：11
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