Strategies for targeted drug delivery in treatment of colon cancer: current trends and future perspectives

被引：190

作者：

Banerjee, Antara ^{[1
]}

Pathak, Surajit ^{[1
]}

Subramanium, Vimala Devi ^{[1
]}

Dharanivasan, G. ^{[2
]}

Murugesan, Ramachandran ^{[1
]}

Verma, Rama S. ^{[2
]}

机构：

[1] CARE, Chennai 603103, Tamil Nadu, India

[2] Indian Inst Technol Madras, Dept Biotechnol, Bhupat & Jyoti Mehta Sch Biosci, Chennai 600036, Tamil Nadu, India

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 08期

关键词：

WALLED CARBON NANOTUBES; COLORECTAL-CANCER; NANOPARTICLES; DENDRIMER; CELLS; THERAPY; ACID; 5-FLUOROURACIL; MICROSPHERES; INTEGRINS;

D O I：

10.1016/j.drudis.2017.05.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite advances in treatment modalities, colon cancer (CC) is the third most common cause of cancer related death worldwide. Subsequent unfavorable effects owing to toxicity of conventional drugs are a challenging problem associated with chemotherapy. There is noticeable concern toward site-specific/targeted delivery of chemotherapeutic drugs specifically to the affected site of the colon in a predictable and reproducible manner. However, the biggest challenge in successful drug targeting for the colon is avoidance of drug absorption and/or degradation in the upper gastrointestinal tract before the drug reaches the colon. Nanoparticles endowed with targeting abilities offer a novel approach for site-specific delivery of chemotherapeutic agents. The present review focuses on recent approaches for colon-specific drug delivery (CDDS) and aims to unveil the emerging possibilities and advances in the treatment of CC with CDDS.

引用

页码：1224 / 1232

页数：9

共 83 条

[81] EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery [J].