Cytopathic hypoxia - Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis

被引：221
作者：
Fink, MP [1 ]
机构：
[1] Univ Pittsburgh, Med Ctr, Sch Med, Div Crit Care Med, Pittsburgh, PA 15261 USA
来源：
CRITICAL CARE CLINICS | 2001年 / 17卷 / 01期
关键词：
D O I：
10.1016/S0749-0704(05)70161-5
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The most common cause of death among critically ill patients with sepsis is multiple organ dysfunction syndrome (MODS). The pathophysiological basis for organ dysfunction in sepsis remains poorly understood. One important factor, however, may be alterations in energy metabolism caused by intrinsic derangements in the metabolic machinery of cells. This phenomenon has been termed cytopathic hypoxia.
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页码：219 / +
页数：20
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