Cytopathic hypoxia - Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis

被引：222

作者：

Fink, MP ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Sch Med, Div Crit Care Med, Pittsburgh, PA 15261 USA

来源：

CRITICAL CARE CLINICS | 2001年 / 17卷 / 01期

关键词：

D O I：

10.1016/S0749-0704(05)70161-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The most common cause of death among critically ill patients with sepsis is multiple organ dysfunction syndrome (MODS). The pathophysiological basis for organ dysfunction in sepsis remains poorly understood. One important factor, however, may be alterations in energy metabolism caused by intrinsic derangements in the metabolic machinery of cells. This phenomenon has been termed cytopathic hypoxia.

引用

页码：219 / +

页数：20

共 96 条

[1] TISSUE METABOLITE LEVELS IN DIFFERENT TYPES OF SKELETAL-MUSCLE DURING SEPSIS [J].

ANGERAS, U ;

HALLANGERAS, M ;

WAGNER, KR ;

JAMES, H ;

HASSELGREN, PO ;

FISCHER, JE .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1991, 40 (11) :1147-1151

[2]

ASTIZ M, 1988, CIRC SHOCK, V26, P311

[3] SEQUENTIAL INSULT ENHANCES LIVER MACROPHAGE-SIGNALED HEPATOCYTE DYSFUNCTION [J].

BANKEY, PE ;

HILL, S ;

GELDON, D .

JOURNAL OF SURGICAL RESEARCH, 1994, 57 (01) :185-191

[4] HEPATIC ACUTE PHASE PROTEIN-SYNTHESIS IS INDIRECTLY REGULATED BY TUMOR-NECROSIS-FACTOR [J].

BANKEY, PE ;

MAZUSKI, JE ;

ORTIZ, M ;

FULCO, JM ;

CERRA, FB .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1990, 30 (10) :1181-1188

[5]

Barcroft J., 1920, LANCET, V2, P485, DOI [10.1016/S0140-6736(00)54692-3, DOI 10.1016/S0140-6736(00)54692-3]

[6] PRELIMINARY STUDIES OF ENERGY-RICH PHOSPHAGENS IN MUSCLE FROM SEVERELY ILL PATIENTS [J].

BERGSTROM, J ;

BOSTROM, H ;

FURST, P ;

HULTMAN, E ;

VINNARS, E .

CRITICAL CARE MEDICINE, 1976, 4 (04) :197-204

[7] Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia [J].

Boczkowski, J ;

Lisdero, CL ;

Lanone, S ;

Samb, A ;

Carreras, MC ;

Boveris, A ;

Aubier, M ;

Poderoso, JJ .

FASEB JOURNAL, 1999, 13 (12) :1637-1646

[8] SKELETAL-MUSCLE PARTIAL-PRESSURE OF OXYGEN IN PATIENTS WITH SEPSIS [J].

BOEKSTEGERS, P ;

WEIDENHOFER, S ;

KAPSNER, T ;

WERDAN, K .

CRITICAL CARE MEDICINE, 1994, 22 (04) :640-650

[9] PERIPHERAL OXYGEN AVAILABILITY WITHIN SKELETAL-MUSCLE IN SEPSIS AND SEPTIC SHOCK - COMPARISON TO LIMITED INFECTION AND CARDIOGENIC-SHOCK [J].

BOEKSTEGERS, P ;

WEIDENHOFER, S ;

PILZ, G ;

WERDAN, K .

INFECTION, 1991, 19 (05) :317-323

[10] Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide [J].

Borutaite, V ;

Brown, GC .

BIOCHEMICAL JOURNAL, 1996, 315 :295-299

← 1 2 3 4 5 6 7 8 9 10 →