Co-regulated expression of matrix metalloproteinase-2 and transforming growth factor-β in melanoma development and progression

被引：27

作者：

Malaponte, Grazia ^{[1
]}

Zacchia, Alessandra ^{[1
]}

Bevelacqua, Ylenia ^{[2
]}

Marconi, Andrea ^{[1
]}

Perrotta, Rosario ^{[2
]}

Mazzarino, Maria Clorinda ^{[1
]}

Cardile, Vera ^{[3
]}

Stivala, Franca ^{[1
]}

机构：

[1] Azienda Osped Cannizzaro, Dept Biomed Sci, Catania, Italy

[2] Azienda Osped Cannizzaro, Plast Surg Sect, Dept Med & Surg Special, Catania, Italy

[3] Univ Catania, Dept Physiol Sci, I-95123 Catania, Italy

来源：

ONCOLOGY REPORTS | 2010年 / 24卷 / 01期

关键词：

MMP-2; TGF-beta; cytokines; melanoma; TGF-BETA; MALIGNANT-MELANOMA; TUMOR INVASION; IV COLLAGENASE; MMP-2; ACTIVATION; TGF-BETA-1; INVASIVENESS; BIOMARKERS;

D O I：

10.3892/or_00000831

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous studies have found that matrix metalloproteinase-2 (MMP-2) and transforming growth factor-beta (TGF-beta) can be considered as biomarkers and indices of disease progression in several human cancers. In this study, we investigated the plasma levels of MMP-2 and TGF-beta and their correlation in 49 primary cutaneous melanoma and 10 metastatic melanoma. Plasma MMP-2 and TGF-beta levels in patients with primary melanoma were significantly higher than those of healthy controls. These protein levels were significantly higher in patients with metastatic melanoma. A positive correlation between plasma levels of MMP-2 and TGF-beta in melanoma patients supports the hypothesis that TGF-beta triggers the release of MMP-2. The immunohistochemistry analysis shows that MMP-2 and TGF-beta were highly expressed in tumor tissues as well as in matched plasma samples. This finding suggests that these proteins are released from tumor cells. Overall, our data indicate that MMP-2 and TGF-beta may represent novel diagnostic markers and therapeutic targets in melanoma and the determination of their concentration could be a useful diagnostic and prognostic indicator. TGF-beta, leading the tissue invasion mediated by MMP-2, is a strong promoter of tumor progression. Therefore, reducing or blocking the activity of TGF-beta may represent a promising target in therapeutic strategies for limiting the growth of melanoma.

引用

页码：81 / 87

页数：7

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