Neurobiological Substrates of Tourette's Disorder

被引：129

作者：

Leckman, James F. ^{[1
,3
,5
]}

Bloch, Michael H. ^{[4
]}

Smith, Megan E.

Larabi, Daouia ^{[6
]}

Hampson, Michelle ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA

[2] Yale Univ, Dept Diagnost Radiol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Pediat, New Haven, CT 06520 USA

[4] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[5] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[6] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands

来源：

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY | 2010年 / 20卷 / 04期

关键词：

TRANSCRANIAL MAGNETIC STIMULATION; OBSESSIVE-COMPULSIVE DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DOPAMINE TRANSPORTER BINDING; RANDOMIZED CONTROLLED-TRIAL; BASAL GANGLIA OUTPUT; TIC DISORDERS; DOUBLE-BLIND; FUNCTIONAL NEUROANATOMY; GABAERGIC INTERNEURONS;

D O I：

10.1089/cap.2009.0118

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD). Methods: The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms. Results: Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation. Conclusion: Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates.

引用

页码：237 / 247

页数：11

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