Obesity and cognitive decline: role of inflammation and vascular changes

被引：311

作者：

Nguyen, Jason C. D. ^{[1
]}

Killcross, A. Simon ^{[2
]}

Jenkins, Trisha A. ^{[1
]}

机构：

[1] RMIT Univ, Sch Med Sci, Hlth Innovat Res Inst, Discipline Pharmaceut Sci, Bundoora, Vic 3083, Australia

[2] UNSW Australia, Sch Psychol, Sydney, NSW, Australia

来源：

FRONTIERS IN NEUROSCIENCE | 2014年 / 8卷

关键词：

memory; hippocampus; cytokines; dementia; Alzheimer's disease; neuroinflammation; BLOOD-BRAIN-BARRIER; BODY-MASS INDEX; HIGH-FAT DIET; BETA-AMYLOID GENERATION; LONG-TERM POTENTIATION; HIGH CHOLESTEROL DIET; C-REACTIVE PROTEIN; HIGH-ENERGY DIET; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;

D O I：

10.3389/fnins.2014.00375

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The incidence of obesity in middle age is increasing markedly, and in parallel the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia. In this review we discuss the effects of obesity on cognitive performance, including both clinical and preclinical observations, and discuss some of the potential mechanisms involved, namely inflammation and vascular and metabolic alterations.

引用

页数：9

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