Chemical constituents from Lycium barbarum (Solanaceae) and their chemophenetic significance

被引：35

作者：

Chen, Dongjie ^{[1
]}

Guo, Sheng ^{[1
]}

Zhou, Junfei ^{[1
]}

Zhu, Yue ^{[1
]}

Zhang, Fang ^{[1
]}

Zeng, Fei ^{[1
]}

Duan, Ran ^{[2
]}

Xu, Mingming ^{[1
]}

Duan, Jin-ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Res, Natl & Local Collaborat Engn Ctr Chinese Med Res, State Adm Tradit Chinese Med Key Lab Chinese Med, Nanjing 210023, Peoples R China

[2] Ningxia Innovat Ctr Goji R & D, Yinchuan, Ningxia, Peoples R China

来源：

BIOCHEMICAL SYSTEMATICS AND ECOLOGY | 2021年 / 97卷

基金：

中国国家自然科学基金;

关键词：

Lycium barbarum; Alkaloid; Lycibarbarspermidine; Chemophenetic; Anti-inflammatory activity; DERIVATIVES; ALKALOIDS; ROOTS; INHIBITION;

D O I：

10.1016/j.bse.2021.104292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the fruit of Lycium barbarum L. has yielded nine alkaloids including one new compound, lycibarbarspermidine T together with eight known compounds. The structures were unambiguously determined by spectroscopic analyses and chemical methods. The chemophenetic significance of all these compounds was summarized. Among the known compounds, compounds 6 and 9 are reported from L. barbarum for the first time, whereas compounds 2-5 have previously been only found in this plant. The anti-inflammatory effects of all compounds were evaluated by measuring the NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS). The results showed that compounds 1-3 and compounds 5-9 could inhibit the NO release of RAW 264.7 cells stimulated by LPS at 30 mu M.

引用

页数：6

共 33 条

[1] Chemical profiling of spermidines in goji berry by strong cation exchange solid-phase extraction (SCX-SPE) combined with ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS/MS) [J].