A consensus document for the clinical management of invasive fungal diseases in pediatric patients with hematologic cancer and/or undergoing hematopoietic stem cell transplantation in Brazilian medical centers

被引：9

作者：

Carlesse, Fabianne ^{[1
,2
]}

Daudt, Liane Esteves ^{[3
]}

Seber, Adriana ^{[4
,5
]}

Dutra, Alvaro Pimenta ^{[6
]}

de Azevedo Melo, Analy Salles ^{[7
]}

Simoes, Belinda ^{[8
]}

Donato Macedo, Carla Renata ^{[1
]}

Bonfim, Carmem ^{[9
]}

Benites, Eliana ^{[10
]}

Gregianin, Lauro ^{[11
]}

Batista, Marjorie Vieira ^{[12
]}

Abramczyk, Marcelo ^{[13
,14
]}

Tostes, Vivian ^{[15
]}

Lederman, Henrique Manoel ^{[1
]}

de Martino Lee, Maria Lucia ^{[16
,17
]}

Loggetto, Sandra ^{[18
]}

de Castro Junior, Claudio Galvao ^{[19
]}

Colombo, Arnaldo Lopes ^{[20
]}

机构：

[1] Univ Fed Sao Paulo, Inst Oncol Pediat, Sao Paulo, SP, Brazil

[2] Univ Fed Sao Paulo, UNIFESP, Escola Paulista Med, Sao Paulo, SP, Brazil

[3] Univ Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

[4] Hosp Samaritano Sao Paulo, Sao Paulo, SP, Brazil

[5] ABHH, Sao Paulo, SP, Brazil

[6] Santa Casa Belo Horizonte, Belo Horizonte, MG, Brazil

[7] Univ Fed Sao Paulo UNIFESP, Lab Especial Micol LEMI, Sao Paulo, SP, Brazil

[8] Hosp Clin Ribeirao Preto USP, Sao Paulo, SP, Brazil

[9] Hosp Clin Curitiba, Curitiba, Parana, Brazil

[10] GREENDAC, Jundiai, SP, Brazil

[11] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

[12] Univ Sao Paulo, Hosp Clin, Fac Med, Sao Paulo, SP, Brazil

[13] Hosp Infantil Darcy Vargas, Morumbi, SP, Brazil

[14] Univ Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, SP, Brazil

[15] Proimagem Med Diagnost Ribeirao Preto, Ribeirao Preto, SP, Brazil

[16] Hosp Santa Marcelina TUCA, Sao Paulo, SP, Brazil

[17] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil

[18] Hosp Infantil Sabara, Sao Paulo, SP, Brazil

[19] Santa Casa Porto Alegre, Porto Alegre, RS, Brazil

[20] Univ Fed Sao Paulo, Disciplina Infectol, Escola Paulista Med, Sao Paulo, SP, Brazil

来源：

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES | 2019年 / 23卷 / 06期

关键词：

Fungal infections; Children; Cancer; BONE-MARROW; RISK-FACTORS; PULMONARY ASPERGILLOSIS; ANTIFUNGAL PROPHYLAXIS; ACUTE-LEUKEMIA; INFECTIONS; CHILDREN; DIAGNOSIS; CANDIDIASIS; RECIPIENTS;

D O I：

10.1016/j.bjid.2019.09.005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In the present paper we summarize the suggestions of a multidisciplinary group including experts in pediatric oncology and infectious diseases who reviewed the medical literature to elaborate a consensus document (CD) for the diagnosis and clinical management of invasive fungal diseases (IFDs) in children with hematologic cancer and those who underwent hematopoietic stem-cell transplantation. All major multicenter studies designed to characterize the epidemiology of IFDs in children with cancer, as well as all randomized clinical trials addressing empirical and targeted antifungal therapy were reviewed. In the absence of randomized clinical trials, the best evidence available to support the recommendations were selected. Algorithms for early diagnosis and best clinical management of IFDs are also presented. This document summarizes practical recommendations that will certainly help pediatricians to best treat their patients suffering of invasive fungal diseases. (C) 2019 Sociedade Brasileira de Infectologia. Published by Elsevier Espana, S.L.U.

引用

页码：395 / 409

页数：15

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