Emerging role of non-coding RNAs in glucose metabolic reprogramming and chemoresistance in colorectal cancer

被引：3
作者：
Yan, Shushan [1 ]
Wang, Shufeng [2 ]
Wang, Xinyi [3 ]
Dai, Wenqing [4 ]
Chu, Jinjin [4 ]
Cheng, Min [5 ]
Guo, Zhiliang [6 ]
Xu, Donghua [4 ,7 ]
机构：
[1] Weifang Med Univ, Affiliated Hosp, Dept Gastrointestinal & Anal Dis Surg, Weifang, Peoples R China
[2] Weifang Med Univ, Med Expt Training Ctr, Weifang, Peoples R China
[3] Shandong First Med Univ, Clin Med Basic Med Sch, Jinan, Peoples R China
[4] Weifang Med Univ, Cent Lab, Affiliated Hosp 1, Weifang, Peoples R China
[5] Weifang Med Univ, Dept Physiol, Weifang, Peoples R China
[6] 80th Grp Army Hosp Chinese Peoples Liberat Army PL, Dept Spine Surg, Weifang, Peoples R China
[7] Weifang Med Univ, Dept Rheumatol, Affiliated Hosp 1, Weifang, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
Circular RNA; colorectal cancer; glucose metabolism; long noncoding RNA; metabolic reprogramming; microRNA; COLON-CANCER; AEROBIC GLYCOLYSIS; LACTATE-DEHYDROGENASE; CELLS; PROMOTES; PROLIFERATION; INHIBITION; AXIS; TRANSFORMATION; EXPRESSION;
D O I：
10.3389/fonc.2022.954329
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metabolic reprogramming plays a critical role in colorectal cancer (CRC). It contributes to CRC by shaping metabolic phenotypes and causing uncontrolled proliferation of CRC cells. Glucose metabolic reprogramming is common in carcinogenesis and cancer progression. Growing evidence has implicated the modifying effects of non-coding RNAs (ncRNAs) in glucose metabolic reprogramming and chemoresistance in CRC. In this review, we have summarized currently published studies investigating the role of ncRNAs in glucose metabolic alterations and chemoresistance in CRC. Elucidating the interplay between ncRNAs and glucose metabolic reprogramming provides insight into exploring novel biomarkers for the diagnosis and prognosis prediction of CRC.
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页数：11
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