Roles of the tissue-type plasminogen activator in immune response

被引：25
作者：
Seillier, Celia [1 ]
Helie, Pauline [1 ,5 ]
Petit, Gautier [1 ,2 ]
Vivien, Denis [1 ,3 ]
Clemente, Diego [4 ]
Le Mauff, Brigitte [1 ,2 ]
Docagne, Fabian [1 ]
Toutirais, Olivier [1 ,2 ]
机构：
[1] Normandie Univ, UNICAEN, INSERM,UMR S U1237,Physiopathol & Imaging Neurol, GIP Cyceron,Inst Blood & Brain Caen Normandie BB, Caen, France
[2] CHU Caen, Dept Immunol & Histocompatibil HLA, Caen Univ Hosp, Caen, France
[3] CHU Caen, Dept Clin Res, Caen Univ Hosp, Caen, France
[4] Hosp Nacl Paraplejicos, Grp Neuroinmunoreparac, Finca La Peraleda S-N, Toledo 45071, Spain
[5] Univ Bern, Theodor Kocher Inst, Freiestr 1, CH-3012 Bern, Switzerland
来源：
CELLULAR IMMUNOLOGY | 2022年 / 371卷
关键词：
Tissue-type plasminogen activator; Plasminogen activation system; Plasmin; T cells; Antigen presenting cells; Macrophages; Immunopathology; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PROTEASE INHIBITOR NEUROSERPIN; CHEMOKINE RECEPTOR CCR7; NF-KAPPA-B; DENDRITIC CELLS; MOLECULAR REQUIREMENTS; MACROPHAGE ACTIVATION; HUMAN-MONOCYTES; NMDA RECEPTORS; IN-VITRO;
D O I：
10.1016/j.cellimm.2021.104451
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The COVID-19 pandemic has once again brought to the forefront the existence of a tight link between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type plasminogen activator (tPA) is a serine protease with a key role in fibrinolysis by converting plasminogen into plasmin that can finally degrade fibrin clots. tPA is released in the blood by endothelial cells and hepatocytes but is also produced by various types of immune cells including T cells and monocytes. Beyond its role on hemostasis, tPA is also a potent modulator of inflammation and is involved in the regulation of several inflammatory diseases. Here, after a brief description of tPA structure, we review its new functions in adaptive immunity focusing on T cells and antigen presenting cells. We intend to synthesize the recent knowledge on proteolysis-and receptor-mediated effects of tPA on immune response in physiological and pathological context.
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页数：8
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共 85 条
  • [31] Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from plasmin-stimulated macrophages
    Li, Qun
    Laumonnier, Yves
    Syrovets, Tatiana
    Simmet, Thomas
    [J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 45 (07) : 593 - 600
  • [32] Plasmin Triggers Chemotaxis of Monocyte-Derived Dendritic Cells Through an Akt2-Dependent Pathway and Promotes a T-Helper Type-1 Response
    Li, Xuehua
    Syrovets, Tatiana
    Genze, Felicitas
    Pitterle, Kai
    Oberhuber, Alexander
    Orend, Karl-Heinz
    Simmet, Thomas
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (03) : 582 - 590
  • [33] Tissue-type plasminogen activator modulates macrophage M2 to M1 phenotypic change through annexin A2-mediated NF-κB pathway
    Lin, Ling
    Hu, Kebin
    [J]. ONCOTARGET, 2017, 8 (50) : 88094 - 88103
  • [34] Tissue-type Plasminogen Activator (tPA) Promotes M1 Macrophage Survival through p90 Ribosomal S6 Kinase (RSK) and p38 Mitogen-activated Protein Kinase (MAPK) Pathway
    Lin, Ling
    Jin, Yang
    Hu, Kebin
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (12) : 7910 - 7917
  • [35] Lin L, 2014, AM J CLIN EXP IMMUNO, V3, P30
  • [36] Tissue Plasminogen Activator Activates NF-κB through a Pathway Involving Annexin A2/CD11b and Integrin-Linked Kinase
    Lin, Ling
    Wu, Chuanyue
    Hu, Kebin
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (08): : 1329 - 1338
  • [37] Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity
    Liot, Geraldine
    Roussel, Benoit D.
    Lebeurrier, Nathalie
    Benchenane, Karim
    Lopez-Atalaya, Jose P.
    Vivien, Denis
    Ali, Carine
    [J]. JOURNAL OF NEUROCHEMISTRY, 2006, 98 (05) : 1458 - 1464
  • [38] Diversity, Mechanisms, and Significance of Macrophage Plasticity
    Locati, Massimo
    Curtale, Graziella
    Mantovani, Alberto
    [J]. ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020, 2020, 15 : 123 - 147
  • [39] Neuroserpin regulates human T cell-T cell interactions and proliferation through inhibition of tissue plasminogen activator
    Loef, Evert Jan
    Brooks, Anna E. S.
    Lorenz, Natalie
    Birch, Nigel P.
    Dunbar, P. Rod
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2020, 107 (01) : 145 - 158
  • [40] Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity
    Lopez-Atalaya, Jose P.
    Roussel, Benoit D.
    Levrat, Denis
    Parcq, Jerome
    Nicole, Olivier
    Hommet, Yannick
    Benchenane, Karim
    Castel, Herve
    Leprince, Jerome
    Van, Denis To
    Bureau, Ronan
    Rault, Sylvain
    Vaudry, Hubert
    Petersen, Karl-Uwe
    Santos, Jana Sopkova-de Oliveira
    Ali, Carine
    Vivien, Denis
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2008, 28 (06) : 1212 - 1221
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