Roles of the tissue-type plasminogen activator in immune response

被引：25
作者：
Seillier, Celia [1 ]
Helie, Pauline [1 ,5 ]
Petit, Gautier [1 ,2 ]
Vivien, Denis [1 ,3 ]
Clemente, Diego [4 ]
Le Mauff, Brigitte [1 ,2 ]
Docagne, Fabian [1 ]
Toutirais, Olivier [1 ,2 ]
机构：
[1] Normandie Univ, UNICAEN, INSERM,UMR S U1237,Physiopathol & Imaging Neurol, GIP Cyceron,Inst Blood & Brain Caen Normandie BB, Caen, France
[2] CHU Caen, Dept Immunol & Histocompatibil HLA, Caen Univ Hosp, Caen, France
[3] CHU Caen, Dept Clin Res, Caen Univ Hosp, Caen, France
[4] Hosp Nacl Paraplejicos, Grp Neuroinmunoreparac, Finca La Peraleda S-N, Toledo 45071, Spain
[5] Univ Bern, Theodor Kocher Inst, Freiestr 1, CH-3012 Bern, Switzerland
来源：
CELLULAR IMMUNOLOGY | 2022年 / 371卷
关键词：
Tissue-type plasminogen activator; Plasminogen activation system; Plasmin; T cells; Antigen presenting cells; Macrophages; Immunopathology; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PROTEASE INHIBITOR NEUROSERPIN; CHEMOKINE RECEPTOR CCR7; NF-KAPPA-B; DENDRITIC CELLS; MOLECULAR REQUIREMENTS; MACROPHAGE ACTIVATION; HUMAN-MONOCYTES; NMDA RECEPTORS; IN-VITRO;
D O I：
10.1016/j.cellimm.2021.104451
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The COVID-19 pandemic has once again brought to the forefront the existence of a tight link between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type plasminogen activator (tPA) is a serine protease with a key role in fibrinolysis by converting plasminogen into plasmin that can finally degrade fibrin clots. tPA is released in the blood by endothelial cells and hepatocytes but is also produced by various types of immune cells including T cells and monocytes. Beyond its role on hemostasis, tPA is also a potent modulator of inflammation and is involved in the regulation of several inflammatory diseases. Here, after a brief description of tPA structure, we review its new functions in adaptive immunity focusing on T cells and antigen presenting cells. We intend to synthesize the recent knowledge on proteolysis-and receptor-mediated effects of tPA on immune response in physiological and pathological context.
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页数：8
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共 85 条
  • [1] Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation
    Andronicos, Nicholas M.
    Chen, Emily I.
    Baik, Nagyung
    Bai, Hongdong
    Parmer, Caitlin M.
    Kiosses, William B.
    Kamps, Mark P.
    Yates, John R., III
    Parmer, Robert J.
    Miles, Lindsey A.
    [J]. BLOOD, 2010, 115 (07) : 1319 - 1330
  • [2] A critical role for plasminogen in inflammation
    Baker, Sarah K.
    Strickland, Sidney
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (04)
  • [3] IL-10-producing T cells and their dual functions
    Bedke, Tanja
    Muscate, Franziska
    Soukou, Shiwa
    Gagliani, Nicola
    Huber, Samuel
    [J]. SEMINARS IN IMMUNOLOGY, 2019, 44
  • [4] Endogenous Matrix Metalloproteinases 2 and 9 Regulate Activation of CD4+ and CD8+ T cells
    Benson, Heather L.
    Mobashery, Shahriar
    Chang, Mayland
    Kheradmand, Farrah
    Hong, Jeong Soo
    Smith, Gerald N.
    Shilling, Rebecca A.
    Wilkes, David S.
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 44 (05) : 700 - 708
  • [5] Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR
    Bertrand, T.
    Lesept, F.
    Chevilley, A.
    Lenoir, S.
    Aimable, M.
    Briens, A.
    Hommet, Y.
    Bardou, I.
    Parcq, J.
    Vivien, D.
    [J]. CELL DEATH & DISEASE, 2015, 6 : e1924 - e1924
  • [6] Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin
    Borg, Rachael J.
    Samson, Andre L.
    Au, Amanda E. -L.
    Scholzen, Anja
    Fuchsberger, Martina
    Kong, Ying Y.
    Freeman, Roxann
    Mifsud, Nicole A.
    Plebanski, Magdalena
    Medcalf, Robert L.
    [J]. PLOS ONE, 2015, 10 (07):
  • [7] Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
    Bromley, SK
    Thomas, SY
    Luster, AD
    [J]. NATURE IMMUNOLOGY, 2005, 6 (09) : 895 - 901
  • [8] The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and Janus kinase (JAK)/STAT signaling pathways
    Burysek, L
    Syrovets, T
    Simmet, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (36) : 33509 - 33517
  • [9] Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration
    Cao, Chunzhang
    Lawrence, Daniel A.
    Li, Yang
    Von Arnim, Christine Af
    Herz, Joachim
    Su, Enming J.
    Makarova, Alexandra
    Hyman, Bradley T.
    Strickland, Dudley K.
    Zhang, Li
    [J]. EMBO JOURNAL, 2006, 25 (09) : 1860 - 1870
  • [10] Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals
    Casse, Frederic
    Bardou, Isabelle
    Danglot, Lydia
    Briens, Aurelien
    Montagne, Axel
    Parcq, Jerome
    Alahari, Anuradha
    Galli, Thierry
    Vivien, Denis
    Docagne, Fabian
    [J]. JOURNAL OF NEUROSCIENCE, 2012, 32 (15) : 5186 - 5199
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