Balancing natural killer cell activation through paired receptors

被引:389
作者
Martinet, Ludovic [1 ,2 ]
Smyth, Mark J. [1 ,3 ]
机构
[1] QIMR, Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld 4006, Australia
[2] Canc Res Ctr Toulouse, INSERM, Unite Mixte Rech 1037, F-31000 Toulouse, France
[3] Univ Queensland, Sch Med, Herston, Qld 4006, Australia
基金
英国医学研究理事会;
关键词
MHC CLASS-I; DNA-DAMAGE RESPONSE; TRIGGERS NK-CELL; POLIOVIRUS RECEPTOR; INHIBITORY RECEPTOR; ADHESION MOLECULE; DENDRITIC CELLS; T-CELLS; CUTTING EDGE; HLA-E;
D O I
10.1038/nri3799
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections and malignancies. NK cells express a variety of inhibitory and activating receptors that facilitate fine discrimination between damaged and healthy cells. Among them, a family of molecules that bind nectin and nectin-like proteins has recently emerged and has been shown to function as an important regulator of NK cell functions. These molecules include CD226, T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), CD96, and cytotoxic and regulatory T cell molecule (CRTAM). In this Review, we focus on the recent advances in our understanding of how these receptors regulate NK cell biology and of their roles in pathologies such as cancer, infection and autoimmunity.
引用
收藏
页码:243 / 254
页数:12
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