Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis

被引：32

作者：

Cheang, Daniella M. J. ^{[1
]}

Armstrong, Roly J. ^{[1
]}

Akhtar, Wasim M. ^{[1
]}

Donohoe, Timothy J. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

METHODOLOGY COOPERATIVE CATALYSIS; ASYMMETRIC HYDROGENATION; C-H; AMINATION; IRIDIUM; FUNCTIONALIZATION; SUBSTITUTION; NUCLEOPHILES; OLEFINS; SCOPE;

D O I：

10.1039/d0cc00767f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched beta-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.

引用

页码：3543 / 3546

页数：4

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