Synthesis of novel isoxazole functionalized pyrazolo[3,4-b]pyridine derivatives; their anticancer activity

被引：32

作者：

Ravula, Sampath ^{[1
]}

Bobbala, Ramana Reddy ^{[1
]}

Kolli, Balakrishna ^{[1
]}

机构：

[1] Gitam Univ, Dept Chem, Hyderabad 502329, Telangana, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 06期

关键词：

BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; POTENT INHIBITORS; ANTAGONISTS;

D O I：

10.1002/jhet.3968

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel isoxazole functionalized pyrazolo[3,4-b]pyridine derivatives 5a-n were prepared, respectively, initiated from 6-thiophenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 3 through selective N-propargylation, and these N-propargylated compounds 4 were cyclized with aryloximes by using of sodium hypochlorite, and obtained the title products 5a-n. All the final products 5a-n were submitted for anticancer activity against four cancer cell lines such as "HeLa-cervical cancer (CCL-2); COLO 205-colon cancer (CCL-222); HepG2-liver cancer (HB-8065); MCF7-breast cancer (HTB-22)"; Compounds 5c, 5d, and 5h are found to have more prominent anticancer activity at micro molar concentration.

引用

页码：2535 / 2538

页数：4

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