Alemtuzumab-related eosinophilic central nervous system vasculitis

被引：2

作者：

Leach, Oliver A. ^{[1
]}

Hilton, David A. ^{[2
]}

Adams, William ^{[3
]}

Love, Seth ^{[4
]}

Straukiene, Agne ^{[5
]}

机构：

[1] Univ Hosp Plymouth NHS Trust, Derriford Hosp, Dept Neurol, Derriford Rd, Plymouth PL6 8DH, Devon, England

[2] Univ Hosp Plymouth NHS Trust, Dept Neuropathol, Plymouth, Devon, England

[3] Univ Hosp Plymouth NHS Trust, Dept Neuroradiol, Plymouth, Devon, England

[4] North Bristol NHS Trust, Dept Neuropathol, Bristol, Avon, England

[5] Torbay & South Devon NHS Fdn Trust, Dept Neurol, Torquay, England

来源：

MULTIPLE SCLEROSIS JOURNAL | 2020年 / 26卷 / 12期

关键词：

Multiple sclerosis; vasculitis; autoimmune; alemtuzumab; eosinophilic;

D O I：

10.1177/1352458519898113

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 36-year-old woman with relapsing remitting multiple sclerosis (MS) presented with right-sided spasms, focal seizures and neuropsychiatric symptoms 10 months after her first course of alemtuzumab. Magnetic resonance imaging (MRI) brain imaging revealed multiple foci of T2 hyperintensity. Subsequent blood and cerebrospinal fluid (CSF) testing for progressive multifocal leukoencephalopathy (PML), vasculitis and infective causes was negative. A brain biopsy was performed, revealing a prominent perivascular inflammatory infiltrate with multiple immune cells including eosinophils, suggesting eosinophilic vasculitis. The patient was treated successfully with cyclophosphamide. The potential sequelae of alemtuzumab treatment are discussed; this treatable complication should be considered when tests for JC virus are negative.

引用

页码：1602 / 1606

页数：6

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