Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson's Disease

被引：39

作者：

Vallee, Alexandre ^{[1
]}

Lecarpentier, Yves ^{[2
]}

Guillevin, Remy ^{[1
]}

Vallee, Jean-Noel ^{[3
,4
]}

机构：

[1] Univ Poitiers, CHU Poitiers, CNRS, UMR 7348,DACTIM MIS,LMA, F-86021 Poitiers, France

[2] GHEF, Ctr Rech Clin, F-77100 Meaux, France

[3] UPJV, CHU Amiens Picardie, F-80000 Amiens, France

[4] Univ Poitiers, CNRS, UMR 7348, LMA, F-86021 Poitiers, France

来源：

CELLS | 2020年 / 9卷 / 02期

关键词：

circadian rhythms; Parkinson's disease; oxidative stress; neuroinflammation; REV-ERB-ALPHA; ALZHEIMERS-DISEASE; CLOCK GENE; INNATE IMMUNITY; MITOCHONDRIAL DYSFUNCTION; MELATONIN PREVENTS; SUBSTANTIA-NIGRA; HOST RESPONSE; SLEEP; RAT;

D O I：

10.3390/cells9020314

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Parkinson's disease (PD) is one of the main neurodegenerative disease characterized by a progressive degeneration of neurons constituted by dopamine in the substantia nigra pars compacta. The etiologies of PD remain unclear. Aging is the main risk factor for PD. Aging could dysregulate molecular pathways controlling cell homeostatic mechanisms. PD cells are the sites of several metabolic abnormalities including neuroinflammation and oxidative stress. Metabolic structures are driven by circadian rhythms. Biologic rhythms are complex systems interacting with the environment and controlling several physiological pathways. Recent findings have shown that the dysregulation of the circadian rhythms is correlated with PD and its metabolic dysregulations. This review is focused on the key role of circadian rhythms and their impact on neuroinflammation and oxidative stress in Parkinson's disease.

引用

页数：15

共 143 条

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