Withanolides from Physalis coztomatl

被引：14

作者：

Zhang, Huaping ^{[1
]}

Cao, Cong-Mei ^{[1
]}

Gallagher, Robert J. ^{[1
]}

Day, Victor W. ^{[2
]}

Kindscher, Kelly ^{[3
]}

Timmermann, Barbara N. ^{[1
]}

机构：

[1] Univ Kansas, Sch Pharm, Dept Med Chem, Lawrence, KS 66045 USA

[2] Univ Kansas, Smallmol Xray Crystallog Lab, Lawrence, KS 66045 USA

[3] Univ Kansas, Kansas Biol Survey, Lawrence, KS 66045 USA

来源：

PHYTOCHEMISTRY | 2015年 / 109卷

基金：

美国国家科学基金会;

关键词：

Withanolide; Physalis coztomatl; Solanaceae; Physacoztolide; Structure revision; Coagulansin A; ANTIPROLIFERATIVE WITHANOLIDES;

D O I：

10.1016/j.phytochem.2014.10.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six withanolides (1-6), as well as two known withanolides (physachenolide D 7 and withanoside VI 8), were isolated from the aerial parts of Physalis coztomatl (Solanaceae). Structural elucidations of 1-6 were achieved through 2D NMR and other spectroscopic techniques, while the structure of 1 was confirmed by X-ray crystallographic analysis. In addition, the stereochemical orientation of the 17-hydroxy group in withanolides was discussed in relation to C-13 NMR shifts of C-12, 13, 14 and 16. Such analysis established that coagulansin A contains a 17 alpha-hydroxy moiety rather than the reported 17 beta-hydroxy functionality, and has been revised accordingly. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：147 / 153

页数：7

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