Decoupled choice-driven and stimulus-related activity in parietal neurons may be misrepresented by choice probabilities

被引：40

作者：

Zaidel, Adam ^{[1
,2
]}

DeAngelis, Gregory C. ^{[3
]}

Angelaki, Dora E. ^{[2
]}

机构：

[1] Bar Ilan Univ, Gonda Multidisciplinary Brain Res Ctr, IL-52900 Ramat Gan, Israel

[2] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[3] Univ Rochester, Dept Brain & Cognit Sci, Ctr Visual Sci, Rochester, NY 14627 USA

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

关键词：

LATERAL INTRAPARIETAL AREA; DECISION-RELATED ACTIVITY; FEATURE-BASED ATTENTION; SUPERIOR TEMPORAL AREA; HEADING PERCEPTION; VISUAL-CORTEX; PREFRONTAL CORTEX; CORTICAL AREA; NEURAL BASIS; MT;

D O I：

10.1038/s41467-017-00766-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Trial-by-trial correlations between neural responses and choices (choice probabilities) are often interpreted to reflect a causal contribution of neurons to task performance. However, choice probabilities may arise from top-down, rather than bottom-up, signals. We isolated distinct sensory and decision contributions to single-unit activity recorded from the dorsal medial superior temporal (MSTd) and ventral intraparietal (VIP) areas of monkeys during perception of self-motion. Superficially, neurons in both areas show similar tuning curves during task performance. However, tuning in MSTd neurons primarily reflects sensory inputs, whereas choice-related signals dominate tuning in VIP neurons. Importantly, the choice-related activity of VIP neurons is not predictable from their stimulus tuning, and these factors are often confounded in choice probability measurements. This finding was confirmed in a subset of neurons for which stimulus tuning was measured during passive fixation. Our findings reveal decoupled stimulus and choice signals in the VIP area, and challenge our understanding of choice signals in the brain.

引用

页数：13

共 56 条

[41] Independent Category and Spatial Encoding in Parietal Cortex [J].