Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

被引：117

作者：

Carini, Francesco ^{[1
,2
]}

Mazzola, Margherita ^{[1
,3
]}

Rappa, Francesca ^{[1
]}

Jurjus, Abdo ^{[4
,5
]}

Geagea, Alice Gerges ^{[1
,4
]}

Al Kattar, Sahar ^{[4
]}

Bou-Assi, Tarek ^{[6
]}

Jurjus, Rosalyn ^{[5
]}

Damiani, Provvidenza ^{[2
]}

Leone, Angelo ^{[1
]}

Tomasello, Giovanni ^{[1
,2
]}

机构：

[1] Univ Palermo, Sect Human Anat, Dept Expt Biomed & Clin Neurosci, BIONEC, Via Vespro 129, I-90127 Palermo, Italy

[2] Univ Palermo, Sch Med & Surg, AOUP P Giaccone, Palermo, Italy

[3] Euromediterranean Inst Sci & Technol IEMEST, Palermo, Italy

[4] Amer Univ Beirut, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon

[5] George Washington Univ, Dept Anat & Regenerat Biol, Washington, DC USA

[6] Psychiat Hosp Cross, Dept Lab Med, Jal El Dib, Lebanon

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 09期

关键词：

Colorectal cancer; dysbiosis; oxidative stress; antioxidants; review; INFLAMMATORY-BOWEL-DISEASE; GUT MICROBIOTA; CANCER CELLS; RISK; TUMORIGENESIS; RESVERATROL; TOCOPHEROLS; POLYPHENOLS; IMBALANCE; COLITIS;

D O I：

10.21873/anticanres.11882

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.

引用

页码：4759 / 4766

页数：8

共 50 条

[31] Oxidative Stress and Male Infertility: The Protective Role of Antioxidants
Kaltsas, Aris
MEDICINA-LITHUANIA, 2023, 59 (10):
[32] The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing
Deng, Liling
Du, Chenzhen
Song, Peiyang
Chen, Tianyi
Rui, Shunli
Armstrong, David G.
Deng, Wuquan
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
[33] BURN,ENDOTHELIAL DYSFUNCTIONS, AND OXIDATIVE STRESS: THE ROLE OF ANTIOXIDANTS
Sahib, Ahmed S.
Al-Jawad, Faruk H.
Al-Kaisy, Ahmed A.
JOURNAL OF CLINICAL PHARMACOLOGY, 2009, 49 (09): : 1091 - 1091
[34] The Role of Dietary Antioxidants on Oxidative Stress in Diabetic Nephropathy
Gerardo Yanowsky-Escatell, Francisco
Andrade-Sierra, Jorge
Pazarin-Villasenor, Leonardo
Santana-Arciniega, Christian
de Jesus Torres-Vazquez, Eduardo
Samuel Chavez-Iniguez, Jonathan
Angel Zambrano-Velarde, Miguel
Martin Preciado-Figueroa, Francisco
IRANIAN JOURNAL OF KIDNEY DISEASES, 2020, 14 (02) : 81 - 94
[35] Role of oxidative stress and antioxidants in Peyronie's disease
S C Sikka
W J G Hellstrom
International Journal of Impotence Research, 2002, 14 : 353 - 360
[36] The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD
Miklos, Zsuzsanna
Horvath, Ildiko
ANTIOXIDANTS, 2023, 12 (06)
[37] THE ROLE OF ANTIOXIDANTS IN GASTRIC CARCINOGENESIS
CORREA, P
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 1995, 35 (1-2) : 59 - 64
[38] THE ROLE OF ANTIOXIDANTS IN CHEMICAL CARCINOGENESIS
ITO, N
HIROSE, M
JAPANESE JOURNAL OF CANCER RESEARCH, 1987, 78 (10): : 1011 - 1026
[39] Role of oxidative stress and DNA damage in human carcinogenesis
Kryston, Thomas B.
Georgiev, Anastassiya B.
Pissis, Polycarpos
Georgakilas, Alexandros G.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2011, 711 (1-2) : 193 - 201
[40] Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis
Sander, CS
Chang, H
Hamm, F
Elsner, P
Thiele, JJ
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2004, 43 (05) : 326 - 335

← 1 2 3 4 5 →