Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

被引：122

作者：

Carini, Francesco ^{[1
,2
]}

Mazzola, Margherita ^{[1
,3
]}

Rappa, Francesca ^{[1
]}

Jurjus, Abdo ^{[4
,5
]}

Geagea, Alice Gerges ^{[1
,4
]}

Al Kattar, Sahar ^{[4
]}

Bou-Assi, Tarek ^{[6
]}

Jurjus, Rosalyn ^{[5
]}

Damiani, Provvidenza ^{[2
]}

Leone, Angelo ^{[1
]}

Tomasello, Giovanni ^{[1
,2
]}

机构：

[1] Univ Palermo, Sect Human Anat, Dept Expt Biomed & Clin Neurosci, BIONEC, Via Vespro 129, I-90127 Palermo, Italy

[2] Univ Palermo, Sch Med & Surg, AOUP P Giaccone, Palermo, Italy

[3] Euromediterranean Inst Sci & Technol IEMEST, Palermo, Italy

[4] Amer Univ Beirut, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon

[5] George Washington Univ, Dept Anat & Regenerat Biol, Washington, DC USA

[6] Psychiat Hosp Cross, Dept Lab Med, Jal El Dib, Lebanon

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 09期

关键词：

Colorectal cancer; dysbiosis; oxidative stress; antioxidants; review; INFLAMMATORY-BOWEL-DISEASE; GUT MICROBIOTA; CANCER CELLS; RISK; TUMORIGENESIS; RESVERATROL; TOCOPHEROLS; POLYPHENOLS; IMBALANCE; COLITIS;

D O I：

10.21873/anticanres.11882

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.

引用

页码：4759 / 4766

页数：8

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