Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining

In this study, we attempted to further collate existing transcriptome sequencing (mRNA-Seq) data by applying data mining and screening intervertebral disc degeneration (IVDD)-related miRNAs. At the same time, combined with published articles, the miRNAs that have been screened out were further excluded, and only the miRNAs confirmed by the reported studies were retained and reviewed. We obtained 12 pro-IVDD miRNAs and ten anti-IVDD miRNAs using the above screening process, involving 33 literature sources. By reviewing and summarizing the above studies, we preliminarily constructed the regulatory network of miRNA in the pathogenesis of IVDD. This regulatory network comprises many gaps and potential miRNA interactions, and these points may be the breakthrough points for further IVDD-related research. This new review approach can also provide a reference for the mechanistic studies of other diseases.