Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients

被引：5

作者：

Molimard, Chloe ^{[1
,2
]}

L'Huillier, Virginie ^{[3
]}

Overs, Alexis ^{[4
]}

Soret, Christine ^{[1
]}

Algros, Marie-Paule ^{[2
]}

Mougin, Christiane ^{[1
]}

Guenat, David ^{[1
,5
]}

Mauvais, Olivier ^{[3
]}

Pretet, Jean-Luc ^{[1
,5
]}

机构：

[1] CHU Besancon, Ctr Natl Reference Papillomavirus, Bd Fleming, F-25000 Besancon, France

[2] CHU Besancon, Serv Anat & Cytol Pathol, Besancon, France

[3] CHU Besancon, Serv Otorhinolaryngol, Besancon, France

[4] CHU Besancon, Lab Biochim, Besancon, France

[5] Univ Bourgogne Franche Comte, UFC, EA3181, LabEx LipSTIC ANR 11 LABEX 0021, Besancon, France

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2021年 / 49卷 / 07期

关键词：

Head and neck squamous cell carcinoma; human papillomavirus; p16; expression; young patient; biomarker; virus DNA; OROPHARYNGEAL CANCER; OVEREXPRESSION; P16(INK4A); TRENDS; PREVALENCE; INCREASE; FRANCE; MARKER;

D O I：

10.1177/03000605211022534

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which is currently increasing worldwide. We evaluated the prevalence of HPV DNA and p16 expression in HNSCC patients age Methods Thirty-nine patients aged Results The overall prevalence of HPV infection was 11.7%. HPV16 was the only genotype detected in 4/39 and 5/38 patients, and p16 was expressed in 6/39 and 4/38 patients aged <45 years and >= 45 years, respectively. Conclusions HPV-positivity and p16 expression were similar in both age groups. The results suggest that p16 immunohistochemistry may provide a prognosis biomarker for all HNSCCs, not only oropharyngeal cancers, and this should be addressed in large clinical trials.

引用

页数：11

共 40 条

[21] Overexpression of p16ink4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri [J].

Klaes, R ;

Friedrich, T ;

Spitkovsky, D ;

Ridder, R ;

Rudy, W ;

Petry, U ;

Dallenbach-Hellweg, G ;

Schmidt, D ;

Doeberitz, MV .

INTERNATIONAL JOURNAL OF CANCER, 2001, 92 (02) :276-284

[22] A Review of HPV-Related Head and Neck Cancer [J].

Kobayashi, Kazuhiro ;

Hisamatsu, Kenji ;

Suzui, Natsuko ;

Hara, Akira ;

Tomita, Hiroyuki ;

Miyazaki, Tatsuhiko .

JOURNAL OF CLINICAL MEDICINE, 2018, 7 (09)

[23] Human Papillomavirus Testing in Head and Neck Carcinomas Guideline From the College of American Pathologists [J].

Lewis, James S., Jr. ;

Beadle, Beth ;

Bishop, Justin A. ;

Chernock, Rebecca D. ;

Colasacco, Carol ;

Lacchetti, Christina ;

Moncur, Joel Todd ;

Rocco, James W. ;

Schwartz, Mary R. ;

Seethala, Raja R. ;

Thomas, Nicole E. ;

Westra, William H. ;

Faquin, William C. .

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2018, 142 (05) :559-597

[24] Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature [J].

Majchrzak, Ewa ;

Szybiak, Bartosz ;

Wegner, Anna ;

Pienkowski, Piotr ;

Pazdrowski, Jakub ;

Luczewski, Lukasz ;

Sowka, Marcin ;

Golusinski, Pawel ;

Malicki, Julian ;

Golusinski, Wojciech .

RADIOLOGY AND ONCOLOGY, 2014, 48 (01) :1-10

[25] Clinicopathological features of squamous cell carcinoma of the oral cavity and oropharynx in young patients [J].

Martinez, R. C-P ;

Sathasivam, H. P. ;

Cosway, B. ;

Paleri, V. ;

Fellows, S. ;

Adams, J. ;

Kennedy, M. ;

Pearson, R. ;

Long, A. ;

Sloan, P. ;

Robinson, M. .

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 2018, 56 (04) :332-337

[26] Double positivity for HPV-DNA/p16ink4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients [J].

Mena, Marisa ;

Taberna, Miren ;

Tous, Sara ;

Marquez, Sandra ;

Clavero, Omar ;

Quiros, Beatriz ;

Lloveras, Belen ;

Alejo, Maria ;

Leon, Xavier ;

Quer, Miquel ;

Bague, Silvia ;

Mesia, Ricard ;

Nogues, Julio ;

Goma, Montserrat ;

Aguila, Anton ;

Bonfill, Teresa ;

Blazquez, Carmen ;

Guix, Marta ;

Hijano, Rafael ;

Torres, Montserrat ;

Holzinger, Dana ;

Pawlita, Michael ;

Angel Pavon, Miguel ;

Bravo, Ignacio G. ;

de Sanjose, Silvia ;

Xavier Bosch, Francesc ;

Alemany, Laia .

ORAL ONCOLOGY, 2018, 78 :137-144

[27] Prevalence and characteristics of HPV-driven oropharyngeal cancer in France [J].

Mirghani, Haitham ;

Bellera, Carine ;

Delaye, Jessy ;

Dolivet, Gilles ;

Fakhry, Nicolas ;

Bozec, Alexandre ;

Garrel, Renaud ;

Malard, Olivier ;

Jegoux, Franck ;

Maingon, Philippe ;

Sarini, Jerome ;

Noel, Georges ;

Duflo, Suzy ;

Temam, Stephane ;

Lefebvr, Jean-louis ;

Costes-Martineau, Valerie .

CANCER EPIDEMIOLOGY, 2019, 61 :89-94

[28] Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes [J].

Myers, JN ;

Elkins, T ;

Roberts, D ;

Byers, RM .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2000, 122 (01) :44-51

[29] HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis [J].

Ndiaye, Cathy ;

Mena, Marisa ;

Alemany, Laia ;

Arbyn, Marc ;

Castellsague, Xavier ;

Laporte, Louise ;

Bosch, F. Xavier ;

de Sanjose, Silvia ;

Trottier, Helen .

LANCET ONCOLOGY, 2014, 15 (12) :1319-1331

[30] Human papillomavirus as prognostic marker with rising prevalence in neck squamous cell carcinoma of unknown primary: A retrospective multicentre study [J].

Schroeder, Lea ;

Boscolo-Rizzo, Paolo ;

Dal Cin, Elisa ;

Romeo, Salvatore ;

Baboci, Lorena ;

Dyckhoff, Gerhard ;

Hess, Jochen ;

Lucena-Porcel, Carlota ;

Byl, Anne ;

Becker, Nikolaus ;

Alemany, Laia ;

Castellsague, Xavier ;

Quer, Miguel ;

Leon, Xavier ;

Wiesenfarth, Manuel ;

Pawlita, Michael ;

Holzinger, Dana .

EUROPEAN JOURNAL OF CANCER, 2017, 74 :73-81

← 1 2 3 4 →