Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients

被引：5

作者：

Molimard, Chloe ^{[1
,2
]}

L'Huillier, Virginie ^{[3
]}

Overs, Alexis ^{[4
]}

Soret, Christine ^{[1
]}

Algros, Marie-Paule ^{[2
]}

Mougin, Christiane ^{[1
]}

Guenat, David ^{[1
,5
]}

Mauvais, Olivier ^{[3
]}

Pretet, Jean-Luc ^{[1
,5
]}

机构：

[1] CHU Besancon, Ctr Natl Reference Papillomavirus, Bd Fleming, F-25000 Besancon, France

[2] CHU Besancon, Serv Anat & Cytol Pathol, Besancon, France

[3] CHU Besancon, Serv Otorhinolaryngol, Besancon, France

[4] CHU Besancon, Lab Biochim, Besancon, France

[5] Univ Bourgogne Franche Comte, UFC, EA3181, LabEx LipSTIC ANR 11 LABEX 0021, Besancon, France

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2021年 / 49卷 / 07期

关键词：

Head and neck squamous cell carcinoma; human papillomavirus; p16; expression; young patient; biomarker; virus DNA; OROPHARYNGEAL CANCER; OVEREXPRESSION; P16(INK4A); TRENDS; PREVALENCE; INCREASE; FRANCE; MARKER;

D O I：

10.1177/03000605211022534

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which is currently increasing worldwide. We evaluated the prevalence of HPV DNA and p16 expression in HNSCC patients age Methods Thirty-nine patients aged Results The overall prevalence of HPV infection was 11.7%. HPV16 was the only genotype detected in 4/39 and 5/38 patients, and p16 was expressed in 6/39 and 4/38 patients aged <45 years and >= 45 years, respectively. Conclusions HPV-positivity and p16 expression were similar in both age groups. The results suggest that p16 immunohistochemistry may provide a prognosis biomarker for all HNSCCs, not only oropharyngeal cancers, and this should be addressed in large clinical trials.

引用

页数：11

共 40 条

[1] Meta analysis: HPV and p16 pattern determines survival in patients with HNSCC and identifies potential new biologic subtype [J].

Albers, Andreas E. ;

Qian, Xu ;

Kaufmann, Andreas M. ;

Coordes, Annekatrin .

SCIENTIFIC REPORTS, 2017, 7

[2]

Altman DG, 2012, BMC MED, V10, DOI [10.1186/1741-7015-10-51, 10.1371/journal.pmed.1001216]

[3] Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer [J].

Ang, K. Kian ;

Harris, Jonathan ;

Wheeler, Richard ;

Weber, Randal ;

Rosenthal, David I. ;

Nguyen-Tan, Phuc Felix ;

Westra, William H. ;

Chung, Christine H. ;

Jordan, Richard C. ;

Lu, Charles ;

Kim, Harold ;

Axelrod, Rita ;

Silverman, C. Craig ;

Redmond, Kevin P. ;

Gillison, Maura L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (01) :24-35

[4] Evaluation of the efficacy of the 4 tests (p16 immunochemistry, polymerase chain reaction, DNA, and RNA in situ hybridization) to evaluate a human papillomavirus infection in head and neck cancers: a cohort of 348 French squamous cell carcinomas [J].

Augustin, Jeremy ;

Outh-Gauer, Sophie ;

Mandavit, Marion ;

Gasne, Cassandre ;

Grard, Ophelie ;

Denize, Thomas ;

Nervo, Marine ;

Mirghani, Haitham ;

Laccourreye, Ollivier ;

Bonfils, Pierre ;

Bruneval, Patrick ;

Veyer, David ;

Pere, Helene ;

Tartour, Eric ;

Badoual, Cecile .

HUMAN PATHOLOGY, 2018, 78 :63-71

[5]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[6] Prognostic Role of p16 in Nonoropharyngeal Head and Neck Cancer [J].

Bryant, Alex K. ;

Sojourner, Elena J. ;

Vitzthum, Lucas K. ;

Zakeri, Kaveh ;

Shen, Hanjie ;

Nguyen, Cammie ;

Murphy, James D. ;

Califano, Joseph A. ;

Cohen, Ezra E. W. ;

Mell, Loren K. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2018, 110 (12) :1393-1399

[7] Use of p16-INK4A overexpression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial [J].

Carozzi, Francesca ;

Confortini, Massimo ;

Dalla Palma, Paolo ;

Del Mistro, Annarosa ;

Gillio-Tos, Anna ;

De Marco, Laura ;

Giorgi-Rossi, Paolo ;

Pontenani, Giovanni ;

Rosso, Stefano ;

Sani, Cristina ;

Sintoni, Catia ;

Segnan, Nereo ;

Zorzi, Manuel ;

Cuzick, Jack ;

Rizzolo, Raffaella ;

Ronco, Guglielmo .

LANCET ONCOLOGY, 2008, 9 (10) :937-945

[8] Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States [J].

Chaturvedi, Anil K. ;

Engels, Eric A. ;

Anderson, William F. ;

Gillison, Maura L. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (04) :612-619

[9] Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers [J].

Chaturvedi, Anil K. ;

Anderson, William F. ;

Lortet-Tieulent, Joannie ;

Curado, Maria Paula ;

Ferlay, Jacques ;

Franceschi, Silvia ;

Rosenberg, Philip S. ;

Bray, Freddie ;

Gillison, Maura L. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (36) :4550-4559

[10] Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States [J].

Chaturvedi, Anil K. ;

Engels, Eric A. ;

Pfeiffer, Ruth M. ;

Hernandez, Brenda Y. ;

Xiao, Weihong ;

Kim, Esther ;

Jiang, Bo ;

Goodman, Marc T. ;

Sibug-Saber, Maria ;

Cozen, Wendy ;

Liu, Lihua ;

Lynch, Charles F. ;

Wentzensen, Nicolas ;

Jordan, Richard C. ;

Altekruse, Sean ;

Anderson, William F. ;

Rosenberg, Philip S. ;

Gillison, Maura L. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (32) :4294-4301

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