Polymer supported calixarene derivative useful for solid-phase synthesis application

被引：6

作者：

Granata, Giuseppe ^{[1
,2
]}

Consoli, Grazia M. L. ^{[1
]}

Sciuto, Sebastiano ^{[3
]}

Geraci, Corrada ^{[1
]}

机构：

[1] CNR, Ist Chim Biomol, I-95126 Catania, Italy

[2] Univ Catania, Dipartimento Sci Farmaceut, I-95125 Catania, Italy

[3] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 47期

关键词：

Anchored-calixarene; Polymeric resin; Solid-phase synthesis; Phosphoramidite chemistry; Nucleotide-calixarene; STATIONARY PHASES; LIBRARY; PRECONCENTRATION; FIBER; AMIDE;

D O I：

10.1016/j.tetlet.2010.09.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A calix[4]arene derivative has been anchored to carboxyl CPG and TentaGel supports by an easily cleavable ester bond and DMT groups allow a simple loading evaluation via UV-vis spectroscopy. The loading of the calixarene on TentaGel resin has also been estimated by HR-MAS NMR experiments. The potential of the polymer supported calixarenes (9 and 10) in solid phase synthesis has been tested by condensation of four thymine nucleotide units onto the upper rim of the calix[4]arene skeleton. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6139 / 6142

页数：4

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