SXT/R391 Integrative and Conjugative Elements (ICEs) Encode a Novel 'Trap-Door' Strategy for Mobile Element Escape

被引：11

作者：

Ryan, Michael P. ^{[1
]}

Armshaw, Patricia ^{[1
]}

Pembroke, J. Tony ^{[1
]}

机构：

[1] Univ Limerick, Dept Chem & Environm Sci, Mol & Struct Biochem Grp, Mat & Surface Sci Inst, Limerick, Ireland

来源：

FRONTIERS IN MICROBIOLOGY | 2016年 / 7卷

关键词：

integrative conjugative elements (ICEs); UV sensitization; 'Trap-Door' escape; R391; SXT; GENE; DIRECTIONALITY; RECOMBINATION; DIVERSITY; EXCISION; PLASMID; PMERPH; R705;

D O I：

10.3389/fmicb.2016.00829

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Integrative conjugative elements (ICEs) are a class of bacterial mobile elements that have the ability to mediate their own integration, excision, and transfer from one host genome to another by a mechanism of site-specific recombination, self-circularisation, and conjugative transfer. Members of the SXT/R391 ICE family of enterobacterial mobile genetic elements display an unusual UV-inducible sensitization function which results in stress induced killing of bacterial cells harboring the ICE. This sensitization has been shown to be associated with a stress induced overexpression of a mobile element encoded conjugative transfer gene, orf43, a traV homolog. This results in cell lysis and release of a circular form of the ICE. Induction of this novel system may allow transfer of an ICE, enhancing its survival potential under conditions not conducive to conjugative transfer.

引用

页数：6

共 40 条

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