Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma A Multicenter Registry-Based Study

被引：17

作者：

Tomar, Ankit Singh ^{[1
]}

Finger, Paul T. ^{[1
]}

Gallie, Brenda ^{[2
,3
]}

Kivela, Tero T. ^{[4
,5
]}

Mallipatna, Ashwin ^{[2
,3
,27
]}

Zhang, Chengyue ^{[6
]}

Zhao, Junyang ^{[6
]}

Wilson, Matthew W. ^{[7
,8
]}

Brennan, Rachel C. ^{[7
,8
]}

Burges, Michala ^{[7
,8
]}

Kim, Jonathan ^{[9
,10
]}

Berry, Jesse L. ^{[9
,10
]}

Jubran, Rima ^{[9
,10
]}

Khetan, Vikas ^{[11
]}

Ganesan, Suganeswari ^{[11
]}

Yarovoy, Andrey ^{[12
]}

Yarovaya, Vera ^{[12
]}

Kotova, Elena ^{[12
]}

Volodin, Denis ^{[12
]}

Yousef, Yacoub A. ^{[13
]}

Nummi, Kalle ^{[4
,5
]}

Ushakova, Tatiana L. ^{[14
,15
]}

Yugay, Olga, V ^{[14
]}

Polyakov, Vladimir G. ^{[14
,15
]}

Ramirez-Ortiz, Marco A. ^{[16
]}

Esparza-Aguiar, Elizabeth ^{[16
]}

Chantada, Guillermo ^{[26
]}

Schaiquevich, Paula ^{[17
,18
]}

Fandino, Adriana ^{[19
]}

Yam, Jason C. ^{[20
]}

Lau, Winnie W. ^{[20
]}

Lam, Carol P. ^{[20
]}

Sharwood, Phillipa ^{[21
]}

Moorthy, Sonia ^{[22
]}

Long, Quah Boon ^{[22
]}

Essuman, Vera Adobea ^{[23
]}

Renner, Lorna A. ^{[24
]}

Semenova, Ekaterina ^{[1
]}

Catala-Mora, Jaume ^{[25
]}

Correa-Llano, Genoveva ^{[25
]}

Carreras, Elisa ^{[25
]}

机构：

[1] New York Eye Canc Ctr, Dept Ocular Tumor Orbital Dis & Ophthalm Radiat T, New York, NY USA

[2] Princess Margaret Canc Ctr, Eye Canc Clin, Toronto, ON, Canada

[3] Hosp Sick Children, Dept Ophthalmol & Vis Sci, Toronto, ON, Canada

[4] Univ Helsinki, Dept Ophthalmol, Ocular Oncol Serv, Helsinki, Finland

[5] Helsinki Univ Hosp, Helsinki, Finland

[6] Beijing Childrens Hosp, Pediat Oncol Ctr, Beijing, Peoples R China

[7] Univ Tennessee, Hlth Sci Ctr, Dept Ophthalmol, Hamilton Eye Inst,Coll Med, Memphis, TN USA

[8] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[9] Univ Southern Calif, USC Roski Eye Inst, Keck Med Sch, Los Angeles, CA 90007 USA

[10] Childrens Hosp Los Angeles, Vis Ctr, Los Angeles, CA 90027 USA

[11] Sankara Nethralaya, Dept Vitreoretina Serv, Chennai, Tamil Nadu, India

[12] SN Fyodorov Eye Microsurg Fed State Inst, Ocular Oncol Dept, Moscow, Russia

[13] King Hussein Canc Ctr, Dept Surg Ophthalmol, Amman, Jordan

[14] NN Blokhin Natl Med Res Ctr Oncol Russian Federat, SRI Pediat Oncol & Hematol, Moscow, Russia

[15] Med Acad Postgrad Educ, Moscow, Russia

[16] Hosp Infantil Mexico Dr Federico Gomez, Dept Ophthalmol, Mexico City, DF, Mexico

[17] Precis Med Coordinat Hosp JP Garrahan, Buenos Aires, DF, Argentina

[18] Natl Sci & Tech Res Council, CONICET, Buenos Aires, DF, Argentina

[19] Hosp JP Garrahan, Ophthalmol Serv, Buenos Aires, DF, Argentina

[20] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong Eye Hosp, Hong Kong, Peoples R China

[21] Univ Sydney, Sydney Med Sch, Save Sight Inst, Discipline Ophthalmol, Sydney, NSW, Australia

[22] KK Womens & Childrens Hosp, Singapore, Singapore

[23] Univ Ghana, Med Sch, Coll Hlth Sci, Dept Surg,Ophthalmol Unit, Accra, Ghana

[24] Univ Ghana, Med Sch, Coll Hlth Sci, Dept Child Hlth, Accra, Ghana

[25] Hosp St Joan Deu, Retinoblastoma Unit, Dept Ophthalmol, Barcelona, Spain

[26] Hosp St Joan Deu, Hematooncol Serv, Barcelona, Spain

[27] Narayana Nethralaya Eye Hosp, Dept Ocular Oncol, Bangalore, Karnataka, India

来源：

OPHTHALMOLOGY | 2022年 / 129卷 / 08期

关键词：

Advanced; AJCC; Chemotherapy; Enucleation; International; Metastasis; Multicenter; Registry; Retinoblastoma; Staging; AMERICAN JOINT COMMITTEE; CLASSIFICATION;

D O I：

10.1016/j.ophtha.2022.04.022

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To evaluate presenting features, tumor size, and treatment methods for risk of metastatic death due to advanced intraocular retinoblastoma (RB). Design: International, multicenter, registry-based retrospective case series. Participants: A total of 1841 patients with advanced RB. Methods: Advanced RB was defined by 8th edition American Joint Committee on Cancer (AJCC) categories cT2 and cT3 and new AJCC-Ophthalmic Oncology Task Force (OOTF) Size Groups (1: < 50% of globe volume, 2: > 50% but < 2/3, 3: > 2/3, and 4: diffuse infiltrating RB). Treatments were primary enucleation, systemic chemotherapy with secondary enucleation, and systemic chemotherapy with eye salvage. Main Outcome Measures: Metastatic death. Results: The 5-year Kaplan-Meier cumulative survival estimates by patient-level AJCC clinical subcategories were 98% for cT2a, 96% for cT2b, 88% for cT3a, 95% for cT3b, 92% for cT3c, 84% for cT3d, and 75% for cT3e RB. Survival estimates by treatment modality were 96% for primary enucleation, 89% for systemic chemotherapy and secondary enucleation, and 90% for systemic chemotherapy with eye salvage. Risk of metastatic mortality increased with increasing cT subcategory (P < 0.001). Cox proportional hazards regression analysis confirmed a higher risk of metastatic mortality in categories cT3c (glaucoma, hazard ratio [HR], 4.9; P = 0.011), cT3d (intraocular hemorrhage, HR, 14.0; P < 0.001), and cT3e (orbital cellulitis, HR, 19.6; P < 0.001) than in category cT2a and with systemic chemotherapy with secondary enucleation (HR, 3.3; P < 0.001) and eye salvage (HR, 4.9; P < 0.001) than with primary enucleation. The 5-year Kaplan-Meier cumulative survival estimates by AJCC-OOTF Size Groups 1 to 4 were 99%, 96%, 94%, and 83%, respectively. Mortality from metastatic RB increased with increasing Size Group (P < 0.001). Cox proportional hazards regression analysis revealed that patients with Size Group 3 (HR, 10.0; P = 0.002) and 4 (HR, 41.1; P < 0.001) had a greater risk of metastatic mortality than Size Group 1. Conclusions: The AJCC-RB cT2 and cT3 subcategories and size-based AJCC-OOTF Groups 3 (> 2/3 globe volume) and 4 (diffuse infiltrating RB) provided a robust stratification of clinical risk for metastatic death in advanced intraocular RB. Primary enucleation offered the highest survival rates for patients with advanced intraocular RB. (C) 2022 by the American Academy of Ophthalmology.

引用

页码：933 / 945

页数：13

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