Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos

被引：12

作者：

Bao, H. G. ^{[1
]}

Zhao, C. J. ^{[1
]}

Li, J. Y. ^{[1
]}

Wu, Ch. ^{[1
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, Beijing 100094, Peoples R China

来源：

ANIMAL GENETICS | 2007年 / 38卷 / 05期

关键词：

MT-ND5; NADH dehydrogenase; respiratory control ratio; Tibet chicken embryo;

D O I：

10.1111/j.1365-2052.2007.01622.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

NADH dehydrogenase (complex I) couples the oxidation of NADH for the reduction of ubiquinone with the generation of a proton gradient that can be used for the synthesis of ATP. We have found a missense mutation in the MT-ND5 subunit of NADH dehydrogenase in the Tibet chicken breed. In the present study, the mitochondrial respiratory control ratio (RCR) and NADH dehydrogenase activity in Tibet chicken embryonic brain with different genotypes were measured. Significant differences between animals carrying mitochondria with the EF493865.1:m.1627A vs. EF493865.1:m.1627C alleles were observed for RCR and enzyme activity.

引用

页码：514 / 516

页数：3

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