Characterizing the Placebo Response in Adults With ADHD

被引：7

作者：

Ben-Sheetrit, Joseph ^{[1
]}

Peskin, Miriam ^{[2
,6
]}

Newcorn, Jeffrey H. ^{[9
]}

Daniely, Yaron ^{[10
]}

Shbiro, Liat ^{[3
]}

Rotem, Ann ^{[3
]}

Weizman, Abraham ^{[4
,5
,7
]}

Manor, Iris ^{[1
,8
]}

机构：

[1] Geha Mental Hlth Ctr, Petah Tiqwa, Israel

[2] Geha Mental Hlth Ctr, Young Children Dept, Petah Tiqwa, Israel

[3] Geha Mental Hlth Ctr, ADHD Clin, Petah Tiqwa, Israel

[4] Geha Mental Hlth Ctr, Child & Adult Psychiat, Petah Tiqwa, Israel

[5] Geha Mental Hlth Ctr, Res Unit, Petah Tiqwa, Israel

[6] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[7] Tel Aviv Univ, Sackler Fac Med, Felsenstein Med Res Ctr, Tel Aviv, Israel

[8] Tel Aviv Univ, Sackler Fac Med, Psychiat, Tel Aviv, Israel

[9] Mt Sinai Hosp, New York, NY 10029 USA

[10] Hebrew Univ Jerusalem, Yissum Ltd, Jerusalem, Israel

来源：

JOURNAL OF ATTENTION DISORDERS | 2020年 / 24卷 / 03期

关键词：

placebo; nocebo; adult ADHD; nonstimulants; CLINICAL-TRIALS;

D O I：

10.1177/1087054718780328

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: Several ADHD pharmacological trials reported high placebo response (PR) rates. This study aims to characterize the PR in adult ADHD. Method: A retrospective cohort analysis of the placebo arm (140 adults with ADHD, 18-55 yrs, M:F 46.4%-53.6%) of a 6-week randomized, multicenter, double-blind metadoxine study, using Conners' Adult ADHD Rating Scale (CAARS) and the Adult ADHD Self-Report Scale (ASRS), was conducted. Results: Pre-post changes in placebo-treated adults were significant for both the CAARS and ASRS, F(2.9, 404.5) = 61.2, p < .00001, F(2.8, 383.0) = 43.1, p < .00001, respectively. Less than half of the participants had a PR which began early in treatment and persisted; almost 50% had a variable, inconsistent PR. Conclusion: In the current sample, PR in adult ADHD was prominent on both symptom scales and the investigator-rater instrument. Therefore, using investigator ratings as a primary endpoint does not necessarily attenuate PR. Of note, about half of the PR is variable, suggesting unreliable determination of efficacy.

引用

页码：425 / 433

页数：9

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