Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

被引：41

作者：

Alcalay, Roy N. ^{[1
]}

Mejia-Santana, Helen ^{[1
]}

Tang, Ming X. ^{[1
,2
]}

Rakitin, Brian ^{[1
,2
]}

Rosado, Llency ^{[1
]}

Ross, Barbara ^{[2
]}

Verbitsky, Miguel ^{[2
]}

Kisselev, Sergey ^{[2
]}

Louis, Elan D. ^{[1
,2
,3
,4
]}

Comella, Cynthia L. ^{[5
]}

Colcher, Amy ^{[6
]}

Jennings, Danna ^{[7
]}

Nance, Martha A. ^{[8
]}

Bressman, Susan ^{[9
,10
]}

Scott, William K. ^{[11
]}

Tanner, Caroline ^{[12
]}

Mickel, Susan F. ^{[13
]}

Andrews, Howard F. ^{[14
]}

Waters, Cheryl H. ^{[1
]}

Fahn, Stanley ^{[1
]}

Cote, Lucien J. ^{[3
]}

Frucht, Steven J. ^{[1
]}

Ford, Blair ^{[1
]}

Rezak, Michael ^{[15
,16
]}

Novak, Kevin ^{[15
,16
]}

Friedman, Joseph H. ^{[17
,18
]}

Pfeiffer, Ronald ^{[19
]}

Marsh, Laura ^{[20
,21
,22
]}

Hiner, Bradley ^{[23
]}

Siderowf, Andrew ^{[6
]}

Ottman, Ruth ^{[1
,3
,4
,24
]}

Clark, Lorraine N. ^{[2
,25
,26
]}

Marder, Karen S. ^{[1
,2
,3
,27
]}

Caccappolo, Elise ^{[1
,2
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY USA

[2] Columbia Univ, Taub Inst Res Alzheimers Dis Aging Brain, Coll Phys & Surg, New York, NY USA

[3] Columbia Univ, Coll Phys & Surg, Gertrude H Sergievsky Ctr, New York, NY USA

[4] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[5] Movement Disorder Sect, Dept Neurol, Chicago, IL USA

[6] Penn Hosp, Parkinsons Dis & Movement Disorders Ctr, Philadelphia, PA 19107 USA

[7] Inst Neurodegenerat Disorders, New Haven, CT USA

[8] Struthers Parkinsons Ctr, Park Nicollet Clin, Golden Valley, MN USA

[9] Beth Israel Deaconess Med Ctr, Alan & Barbara Mirken Dept Neurol, New York, NY 10003 USA

[10] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA

[11] Univ Miami, Miller Sch Med, John T Macdonald Fdn, Dept Human Genet,Miami Inst Human Genom, Miami, FL 33136 USA

[12] Parkinsons Inst, Sunnyvale, CA USA

[13] Marshfield Clin Fdn Med Res & Educ, Dept Neurol, Marshfield, WI USA

[14] New York State Psychiat Inst & Hosp, Data Coordinating Ctr, New York, NY 10032 USA

[15] NorthShore Univ Hlth Syst, Dept Neurol, Evanston, IL USA

[16] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA

[17] Parkinsons Dis & Movement Disorders Ctr NeuroHlth, Warwick, RI USA

[18] Brown Univ, Warren Alpert Sch Med, Dept Clin Neurosci, Providence, RI 02912 USA

[19] Univ Tennessee, Hlth Sci Ctr, Coll Med, Dept Neurol, Memphis, TN USA

[20] Johns Hopkins Univ, Sch Med, Morris K Udall Parkinsons Dis Res Ctr Excellence, Baltimore, MD USA

[21] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[22] Johns Hopkins Univ, Sch Med, Dept Neurol & Neurol Sci, Baltimore, MD 21205 USA

[23] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[24] New York State Psychiat Inst & Hosp, Div Epidemiol, New York, NY 10032 USA

[25] Columbia Univ, Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY USA

[26] Columbia Univ, Coll Phys & Surg, Ctr Human Genet, New York, NY USA

[27] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 2010年 / 32卷 / 07期

关键词：

Parkin; Leucine-rich repeat kinase-2; Glucocerebrosidase; Parkinson; Cognition; Mini-mental state examination; Genetics; GLUCOCEREBROSIDASE MUTATIONS; GENE; ASSOCIATION; DEMENTIA; FREQUENCY; MORTALITY; PD;

D O I：

10.1080/13803390903521018

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.

引用

页码：775 / 779

页数：5

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