A Facile Synthesis of CF3-Substituted Pyrazolidines and Pyrazolines

被引：17

作者：

Liu, Lili ^{[1
]}

Huang, Danfeng ^{[1
]}

Wang, Yuxiang ^{[1
]}

Wen, Lan ^{[1
]}

Yang, Zheng ^{[1
]}

Su, Yingpeng ^{[1
]}

Wang, Kehu ^{[1
]}

Hu, Yulai ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 06期

基金：

中国国家自然科学基金;

关键词：

trifluoromethyl building blocks; cycloaddition; trifluoromethylated N-acylhydrazones; alkenes; trifluoromethyl pyrazolidines; trifluoromethyl pyrazolines; SILICON LEWIS-ACID; ENANTIOSELECTIVE FLUORINATION; LOCAL-ANESTHETICS; AZOMETHINE IMINES; DERIVATIVES; TRIFLUOROMETHYLATION; ANTIDEPRESSANT; CYCLOADDITION; HYDRAZONES; KETONES;

D O I：

10.6023/cjoc201712036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Lewis acid-catalyzed [3+2] cycloaddition of trifluoromethylated N-acylhydrazones with alkenes was explored, and a series of CF3-substituted pryazolidines were obtained in high yields (up to 91%). The reaction features the use of cheap and readily available trifluoromethylated N-acylhydrazones as trifluoromethyl building blocks, mild reaction conditions and easy operation. Furthermore, the cycloadducts can be transformed into trifluoromethylated pyrazolines in excellent yields.

引用

页码：1469 / 1476

页数：8

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