Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma

被引：36

作者：

Yoon, Jun Sik ^{[1
]}

Kim, Gyeonghwa ^{[2
]}

Lee, Yu Rim ^{[1
]}

Park, Soo Young ^{[1
]}

Tak, Won Young ^{[1
]}

Kweon, Young-Oh ^{[1
]}

Park, Jung Gil ^{[3
]}

Lee, Hye Won ^{[4
]}

Han, Young Seok ^{[5
]}

Ha, Heon Tak ^{[5
]}

Chun, Jae Min ^{[5
]}

Jang, Se Young ^{[1
]}

Hur, Keun ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea

[2] Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea

[3] Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea

[4] Keimyung Univ, Dept Pathol, Sch Med, Daegu, South Korea

[5] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu, South Korea

来源：

BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 10期

关键词：

disease progression; hepatocellular carcinoma; microRNA-21; microRNA-31; prognosis; survival; therapeutics; TRANSARTERIAL CHEMOEMBOLIZATION; RADIOFREQUENCY ABLATION; THERAPEUTIC TARGET; TUMOR-SUPPRESSOR; LUNG-CANCER; HUMAN LIVER; CELLS; PROLIFERATION; HETEROGENEITY; METAANALYSIS;

D O I：

10.2217/bmm-2018-0096

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). Materials & methods: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. Results: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. Conclusion: Elevated miR-21 expression might represent a biomarker for HCC prognosis.

引用

页码：1105 / 1114

页数：10

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