Nonclinical psychotic-like experiences and schizotypy dimensions: Associations with hippocampal subfield and amygdala volumes

被引:2
作者
Evermann, Ulrika [1 ,2 ]
Gaser, Christian [3 ,4 ]
Meller, Tina [1 ,2 ]
Pfarr, Julia-Katharina [1 ,2 ]
Grezellschak, Sarah [1 ,2 ,5 ]
Nenadic, Igor [1 ,2 ,5 ]
机构
[1] Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Cognit Neuropsychiat Lab, Marburg, Germany
[2] Ctr Mind Brain & Behav CMBB, Marburg, Germany
[3] Jena Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany
[4] Jena Univ Hosp, Dept Neurol, Jena, Germany
[5] UKGM, Marburg Univ Hosp, Marburg, Germany
关键词
amygdala; hippocampus; neuroimaging; psychosis proneness; schizotypy; ULTRA-HIGH-RISK; CLINICAL HIGH-RISK; 1ST-EPISODE SCHIZOPHRENIA; NEGATIVE SCHIZOTYPY; EMOTION RECOGNITION; BIPOLAR DISORDER; STATE; INDIVIDUALS; SPECTRUM; STRESS;
D O I
10.1002/hbm.25601
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Schizotypy and psychotic-like experiences (PLE) form part of the wider psychosis continuum and may have brain structural correlates in nonclinical cohorts. This study aimed to compare the effects of differential schizotypy dimensions, PLE, and their interaction on hippocampal subfields and amygdala volumes in the absence of clinical psychopathology. In a cohort of 367 psychiatrically healthy individuals, we assessed schizotypal traits using the Oxford-Liverpool Inventory of Life Experiences (O-LIFE) and PLE using the short form of the Prodromal Questionnaire (PQ-16). Based on high-resolution structural MRI scans, we used automated segmentation to estimate volumes of limbic structures. Sex and total intracranial volume (Step 1), PLE and schizotypy dimensions (Step 2), and their interaction terms (Step 3) were entered as regressors for bilateral amygdala and hippocampal subfield volumes in hierarchical multiple linear regression models. Positive schizotypy, but not PLE, was negatively associated with left amygdala and subiculum volumes. O-LIFE Impulsive Nonconformity, as well as the two-way interaction between positive schizotypy and PLE, were associated with larger left subiculum volumes. None of the estimators for right hemispheric hippocampal subfield volumes survived correction for multiple comparisons. Our findings support differential associations of hippocampus subfield volumes with trait dimensions rather than PLE, and support overlap and interactions between psychometric positive schizotypy and PLE. In a healthy cohort without current psychosis risk syndromes, the positive association between PLE and hippocampal subfield volume occurred at a high expression of positive schizotypy. Further studies combining stable, transient, and genetic parameters are required.
引用
收藏
页码:5075 / 5088
页数:14
相关论文
共 120 条
[1]   Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort [J].
Allen, Paul ;
Azis, Matilda ;
Modinos, Gemma ;
Bossong, Matthijs G. ;
Bonoldi, Ilaria ;
Samson, Carly ;
Quinn, Beverly ;
Kempton, Matthew J. ;
Howes, Oliver D. ;
Stone, James M. ;
Calem, Maria ;
Perez, Jesus ;
Bhattacharayya, Sagnik ;
Broome, Matthew R. ;
Grace, Anthony A. ;
Zelaya, Fernando ;
McGuire, Philip .
SCHIZOPHRENIA BULLETIN, 2018, 44 (06) :1323-1331
[2]   Resting Hyperperfusion of the Hippocampus, Midbrain, and Basal Ganglia in People at High Risk for Psychosis [J].
Allen, Paul ;
Chaddock, Christopher A. ;
Egerton, Alice ;
Howes, Oliver D. ;
Bonoldi, Ilaria ;
Zelaya, Fernando ;
Bhattacharyya, Sagnik ;
Murray, Robin ;
McGuire, Philip .
AMERICAN JOURNAL OF PSYCHIATRY, 2016, 173 (04) :392-399
[3]   Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk [J].
Alnaes, Dag ;
Kaufmann, Tobias ;
van der Meer, Dennis ;
Cordova-Palomera, Aldo ;
Rokicki, Jaroslav ;
Moberget, Torgeir ;
Bettella, Francesco ;
Agartz, Ingrid ;
Barch, Deanna M. ;
Bertolino, Alessandro ;
Brandt, Christine L. ;
Cervenka, Simon ;
Djurovic, Srdjan ;
Nhat Trung Doan ;
Eisenacher, Sarah ;
Fatouros-Bergman, Helena ;
Flyckt, Lena ;
Di Giorgio, Annabella ;
Haatveit, Beathe ;
Jonsson, Erik G. ;
Kirsch, Peter ;
Lund, Martina J. ;
Meyer-Lindenberg, Andreas ;
Pergola, Giulio ;
Schwarz, Emanuel ;
Smeland, Olav B. ;
Quarto, Tiziana ;
Zink, Mathias ;
Andreassen, Ole A. ;
Westlye, Lars T. ;
Farde, Lars ;
Collste, Karin ;
Victorsson, Pauliina ;
Engberg, Goran ;
Erhardt, Sophie ;
Malmqvist, Anna ;
Hedberg, Mikael ;
Orhan, Funda ;
Sellgren, Carl M. ;
Schwieler, Lilly ;
Piehl, Fredrik .
JAMA PSYCHIATRY, 2019, 76 (07) :739-748
[4]   Verbal learning and hippocampal dysfunction in schizophrenia: A meta analysis [J].
Antoniades, Mathilde ;
Schoeler, Tabea ;
Radua, Joaquim ;
Valli, Isabel ;
Allen, Paul ;
Kempton, Matthew J. ;
McGuire, Philip .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2018, 86 :166-175
[5]   Amygdala subnucleus volumes in psychosis high-risk state and first-episode psychosis [J].
Armio, Reetta-Liina ;
Laurikainen, Heikki ;
Ilonen, Tuula ;
Walta, Maija ;
Salokangas, Raimo K. R. ;
Koutsouleris, Nikolaos ;
Hietala, Jarmo ;
Tuominen, Lauri .
SCHIZOPHRENIA RESEARCH, 2020, 215 :284-292
[6]   Hippocampal Subfield Volumes in Patients With First-Episode Psychosis [J].
Baglivo, Valentina ;
Cao, Bo ;
Mwangi, Benson ;
Bellani, Marcella ;
Perlini, Cinzia ;
Lasalvia, Antonio ;
Dusi, Nicola ;
Bonetto, Chiara ;
Cristofalo, Doriana ;
Alessandrini, Franco ;
Zoccatelli, Giada ;
Ciceri, Elisa ;
Dario, Lamonaca ;
Enrico, Ceccato ;
Francesca, Pileggi ;
Mazzi, Fausto ;
Paolo, Santonastaso ;
Balestrieri, Matteo ;
Soares, Jair C. ;
Ruggeri, Mirella ;
Brambilla, Paolo .
SCHIZOPHRENIA BULLETIN, 2018, 44 (03) :552-559
[7]   Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders [J].
Barkhuizen, Wikus ;
Pain, Oliver ;
Dudbridge, Frank ;
Ronald, Angelica .
TRANSLATIONAL PSYCHIATRY, 2020, 10 (01)
[8]   The Role of Schizotypy in the Study of the Etiology of Schizophrenia Spectrum Disorders [J].
Barrantes-Vidal, Neus ;
Grant, Phillip ;
Kwapil, Thomas R. .
SCHIZOPHRENIA BULLETIN, 2015, 41 :S408-S416
[9]   Psychometric Schizotypy Predicts Psychotic-Like, Paranoid, and Negative Symptoms in Daily Life [J].
Barrantes-Vidal, Neus ;
Chun, Charlotte A. ;
Myin-Germeys, Inez ;
Kwapil, Thomas R. .
JOURNAL OF ABNORMAL PSYCHOLOGY, 2013, 122 (04) :1077-1087
[10]   Positive and negative schizotypy are associated with prodromal and schizophrenia-spectrum symptoms [J].
Barrantes-Vidal, Neus ;
Gross, Georgina M. ;
Sheinbaum, Tamara ;
Mitjavila, Merce ;
Ballespi, Sergi ;
Kwapil, Thomas R. .
SCHIZOPHRENIA RESEARCH, 2013, 145 (1-3) :50-55