New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

被引：16

作者：

Roy, Prodip K. ^{[1
]}

Ashimine, Runa ^{[1
]}

Miyazato, Haruna ^{[2
]}

Taira, Junsei ^{[2
]}

Ueda, Katsuhiro ^{[1
]}

机构：

[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, 1 Senbaru, Nishihara, Okinawa 9032013, Japan

[2] Okinawa Natl Coll Technol, Dept Bioresources Engn, 905 Henoko, Nago, Okinawa 9052192, Japan

来源：

MOLECULES | 2016年 / 21卷 / 05期

关键词：

casbane; cembrane; antibacterial; cytotoxicity; HCT; 116; cells; anti-inflammatory; CESPITULARIA SP; CYTOTOXIC CEMBRANOLIDES; ALCYONOLIDE CONGENERS; MICHAELAE; CRASSUM; DURUM;

D O I：

10.3390/molecules21050679

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4-7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/ IFN-gamma-stimulated RAW 264.7 macrophage cells.

引用

页数：9

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