Rapid and efficient synthesis of 1,2,4-oxadiazoles utilizing polymer-supported reagents under microwave heating

被引：98

作者：

Wang, Y ^{[1
]}

Miller, RL ^{[1
]}

Sauer, DR ^{[1
]}

Djuric, SW ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, High Throughput Organ Synth Grp, Abbott Pk, IL 60064 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 05期

关键词：

D O I：

10.1021/ol050007r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2,4-Oxadiazoles can be rapidly and efficiently synthesized from a variety of readily available carboxylic acids and amidoximes using either method A or method B. The use of commercially available polymer-supported reagents combined with microwave heating resulted in high yields and purities of the product 1,2,4-oxadiazoles in an expeditious manner.

引用

页码：925 / 928

页数：4

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