Single-Atom Nanozyme Based on Nanoengineered Fe-N-C Catalyst with Superior Peroxidase-Like Activity for Ultrasensitive Bioassays

被引：256

作者：

Cheng, Nan ^{[1
]}

Li, Jin-Cheng ^{[1
]}

Liu, Dong ^{[1
]}

Lin, Yuehe ^{[1
]}

Du, Dan ^{[1
]}

机构：

[1] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA

来源：

SMALL | 2019年 / 15卷 / 48期

基金：

美国食品与农业研究所;

关键词：

Fe-N-C catalysis; paper bioassays; peroxidase-like activity; single-atom nanozyme; NANOPARTICLES; DEGRADATION; MIMICKING;

D O I：

10.1002/smll.201901485

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single-atom catalysts are becoming a hot research topic owing to their unique characteristics of maximum specific activity and atomic utilization. Herein, a new single-atom nanozyme (SAN) based on single Fe atoms anchored on N-doped carbons supported on carbon nanotube (CNT/FeNC) is proposed. The CNT/FeNC with robust atomic Fe-N-x moieties is synthesised, showing superior peroxidase-like activity. Furthermore, the CNT/FeNC is used as the signal element in a series of paper-based bioassays for ultrasensitive detection of H2O2, glucose, and ascorbic acid. The SAN provides a new type of signal element for developing various biosensing techniques.

引用

页数：7

共 40 条

[1] Degradation and mineralization of methylene blue using a heterogeneous photo-Fenton catalyst under visible and solar light irradiation [J].

Ahmed, Yunus ;

Yaakob, Zahira ;

Akhtar, Parul .

CATALYSIS SCIENCE & TECHNOLOGY, 2016, 6 (04) :1222-1232

[2] Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles [J].

Asati, Atul ;

Santra, Santimukul ;

Kaittanis, Charalambos ;

Nath, Sudip ;

Perez, J. Manuel .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (13) :2308-2312

[3] IN THE ABSENCE OF CATALYTIC METALS ASCORBATE DOES NOT AUTOXIDIZE AT PH-7 - ASCORBATE AS A TEST FOR CATALYTIC METALS [J].

BUETTNER, GR .

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1988, 16 (01) :27-40

[4] Tunable Enhancement of a Graphene/Polyaniline/Poly(ethylene oxide) Composite Electrospun Nanofiber Gas Sensor [J].

Burris A.J. ;

Tran K. ;

Cheng Q. .

Journal of Analysis and Testing, 2017, 1 (2)

[5] Ultrasmall Nanozymes Isolated within Porous Carbonaceous Frameworks for Synergistic Cancer Therapy: Enhanced Oxidative Damage and Reduced Energy Supply [J].

Cao, Fangfang ;

Zhang, Yan ;

Sun, Yuhuan ;

Wang, Zhenzhen ;

Zhang, Lu ;

Huang, Yanyan ;

Liu, Chaoqun ;

Liu, Zhen ;

Ren, Jinsong ;

Qu, Xiaogang .

CHEMISTRY OF MATERIALS, 2018, 30 (21) :7831-7839

[6] Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity [J].

Chen, Zhongwen ;

Yin, Jun-Jie ;

Zhou, Yu-Ting ;

Zhang, Yu ;

Song, Lina ;

Song, Mengjie ;

Hu, Sunling ;

Gu, Ning .

ACS NANO, 2012, 6 (05) :4001-4012

[7] Nanozyme-Mediated Dual Immunoassay Integrated with Smartphone for Use in Simultaneous Detection of Pathogens [J].

Cheng, Nan ;

Song, Yang ;

Zeinhom, Mohamed M. A. ;

Chang, Yu-Chung ;

Sheng, Lina ;

Li, Haolin ;

Du, Dan ;

Li, Lei ;

Zhu, Mei-Jun ;

Luo, Yunbo ;

Xu, Wentao ;

Lin, Yuehe .

ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (46) :40671-40680

[8] Magnetic Fe3S4 nanoparticles with peroxidase-like activity, and their use in a photometric enzymatic glucose assay [J].

Ding, Caiping ;

Yan, Yinghan ;

Xiang, Dongshan ;

Zhang, Cuiling ;

Xian, Yuezhong .

MICROCHIMICA ACTA, 2016, 183 (02) :625-631

[9] Introducing Ratiometric Fluorescence to MnO2 Nanosheet-Based Biosensing: A Simple, Label-Free Ratiometric Fluorescent Sensor Programmed by Cascade Logic Circuit for Ultrasensitive GSH Detection [J].

Fan, Daoqing ;

Shang, Changshuai ;

Gu, Wenling ;

Wang, Erkang ;

Dong, Shaojun .

ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (31) :25870-25877

[10] In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy [J].

Fan, Kelong ;

Xi, Juqun ;

Fan, Lei ;

Wang, Peixia ;

Zhu, Chunhua ;

Tang, Yan ;

Xu, Xiangdong ;

Liang, Minmin ;

Jiang, Bing ;

Yan, Xiyun ;

Gao, Lizeng .

NATURE COMMUNICATIONS, 2018, 9

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