Insights into the structure and architecture of the CCR4-NOT complex

被引：30

作者：

Xu, Kun ^{[1
,2
]}

Bai, Yuwei ^{[1
]}

Zhang, Aili ^{[1
,2
]}

Zhang, Qionglin ^{[2
]}

Bartlam, Mark G. ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

[2] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

来源：

FRONTIERS IN GENETICS | 2014年 / 5卷

关键词：

MESSENGER-RNA DEADENYLATION; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTOR; GENE-EXPRESSION; DIFFERENTIALLY AFFECTS; CRYSTAL-STRUCTURE; BINDING PROTEIN; NUCLEASE MODULE; CAF1; PROTEINS; YEAST;

D O I：

10.3389/fgene.2014.00137

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription initiation and elongation, ubiquitination, and protein modification. The core CCR4-NOT complex is evolutionarily conserved and consists of at least three NOT proteins and two catalytic subunits. The L-shaped complex is characterized by two functional modules bound to the CNOT1/Not1 scaffold protein: the deadenylase or nuclease module containing two enzymes required for deadenylation, and the NOT module. In this review, we will summarize the currently available information regarding the three-dimensional structure and assembly of the CCR4-NOT complex, in order to provide insight into its roles in mRNA degradation and other biological processes.

引用

页数：12

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